Abstract Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study
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Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study

机译：城市养育与儿童呼吸道和过敏性疾病：多国整体研究

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AbstractObjectiveWe integratively assessed the effect of different indoor and outdoor environmental exposures early in life on respiratory and allergic health conditions among children from (sub-) urban areas.MethodsThis study included children participating in four ongoing European birth cohorts located in three different geographical regions: INMA (Spain), LISAplus (Germany), GINIplus (Germany) and BAMSE (Sweden). Wheezing, bronchitis, asthma and allergic rhinitis throughout childhood were assessed using parental-completed questionnaires. We designed “environmental scores” corresponding to different indoor, green- and grey-related exposures (main analysis, a-priori-approach). Cohort-specific associations between these environmental scores and the respiratory health outcomes were assessed using random-effects meta-analyses. In addition, a factor analysis was performed based on the same exposure information used to develop the environmental scores (confirmatory analysis, data-driven-approach).ResultsA higher early exposure to the indoor environmental score increased the risk for wheezing and bronchitis within the first year of life (combined adjusted odds ratio: 1.20 [95% confidence interval: 1.13–1.27] and 1.28 [1.18–1.39], respectively). In contrast, there was an inverse association with allergic rhinitis between 6 and 8 years (0.85 [0.79–0.92]). There were no statistically significant associations for the outdoor related environmental scores in relation to any of the health outcomes tested. The factor analysis conducted confirmed these trends.ConclusionAlthough a higher exposure to indoor related exposure through occupants was associated with an increased risk for wheezing and bronchitis within the 1st year, it might serve as a preventive mechanism against later childhood allergic respiratory outcomes in urbanized environments through enhanced shared contact with microbial agents.Highlights•Suggested higher microbial load indoors was associated with an increased risk of respiratory infections in early childhood.•The same exposure was linked to a decreased risk for asthma and allergic rhinitis in later childhood.•The assumed biological mechanism might be associated with greater family size.
机译： 摘要 客观 我们综合评估了不同室内和室外的影响（亚）城市地区儿童生命早期的呼吸和过敏性健康状况对户外环境的影响。 方法 这项研究包括参与三个不同地理区域的四个正在进行的欧洲出生队列的儿童：INMA（西班牙），LISAplus（德国），GINIplus（德国）和BAMSE（瑞典）。使用父母填写的问卷评估了整个儿童时期的喘息，支气管炎，哮喘和过敏性鼻炎。我们设计了与不同的室内，绿色和灰色相关的暴露量相对应的“环境评分”（主要分析，先验方法）。使用随机效应荟萃分析评估了这些环境评分与呼吸健康结果之间的特定队列关联。此外，基于用于得出环境评分的相同暴露信息（确认分析，数据驱动方法）进行了因子分析。 结果 结论 尽管通过乘员对室内相关暴露的暴露量增加与风险增加有关对于第一年内发生的喘息和支气管炎，它可能通过加强与微生物制剂的共享接触而成为预防城市化环境中儿童后期过敏性呼吸道结局的预防机制。 < / ce：abstract> 突出显示 •• 建议室内较高的微生物负荷与儿童早期呼吸道感染的风险增加有关。 • 在同一儿童中，相同的暴露与哮喘和过敏性鼻炎风险降低有关。 • 假定的生物学机制可能与更大的家庭规模有关。

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  • 来源
    《Environmental research》 |2018年第2期|276-283|共8页
  • 作者

    Christina Tischer; Payam Dadvand; Xavier Basagana; Elaine Fuertes; Anna Bergström; Olena Gruzieva; Erik Melen; Dietrich Berdel; Joachim Heinrich; Sibylle Koletzko; Iana Markevych; Marie Standl; Dorothea Sugiri; Lourdes Cirugeda; Marisa Estarlich; Ana Fernández-Somoano; Amparo Ferrero; Jesus Ibarlueza; Aitana Lertxundi; Adonina Tardón; Jordi Sunyer; Josep M. Anto;

  • 作者单位

    ISGlobal, Barcelona Institute for Global Health - Campus MAR,Universitat Pompeu Fabra (UPF),CIBER Epidemiología y Salud Pública (CIBERESP);

    ISGlobal, Barcelona Institute for Global Health - Campus MAR,Universitat Pompeu Fabra (UPF),CIBER Epidemiología y Salud Pública (CIBERESP);

    ISGlobal, Barcelona Institute for Global Health - Campus MAR,Universitat Pompeu Fabra (UPF),CIBER Epidemiología y Salud Pública (CIBERESP);

    ISGlobal, Barcelona Institute for Global Health - Campus MAR,Universitat Pompeu Fabra (UPF),CIBER Epidemiología y Salud Pública (CIBERESP);

    Institute of Environmental Medicine, Karolinska Institutet,Centre for Occupational and Environmental Medicine, Stockholm County Council;

    Institute of Environmental Medicine, Karolinska Institutet,Centre for Occupational and Environmental Medicine, Stockholm County Council;

    Institute of Environmental Medicine, Karolinska Institutet,Centre for Occupational and Environmental Medicine, Stockholm County Council,Sachs’ Children's Hospital, Södersjukhuset;

    Research Institute, Department of Pediatrics, Marien-Hospital Wesel;

    Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital of Munich (LMU),Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health;

    Division of Paediatric Gastroenterology and Hepatology, Dr. von Hauner Children's Hospital Munich, Ludwig-Maximilians-University of Munich;

    Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital of Munich (LMU),Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health;

    Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health;

    IUF – Leibniz Research Institute for Environmental Medicine;

    ISGlobal, Barcelona Institute for Global Health - Campus MAR,Universitat Pompeu Fabra (UPF),CIBER Epidemiología y Salud Pública (CIBERESP);

    CIBER Epidemiología y Salud Pública (CIBERESP),FISABIO–Universitat de València–Universitat Jaume I Joint Research Unit;

    CIBER Epidemiología y Salud Pública (CIBERESP),IUOPA-Preventive Medicine and Public Health Area, Department of Medicine, University of Oviedo;

    CIBER Epidemiología y Salud Pública (CIBERESP),FISABIO–Universitat de València–Universitat Jaume I Joint Research Unit;

    CIBER Epidemiología y Salud Pública (CIBERESP),Health Research Institute, BIODONOSTIA,Subdireccion de Salud Publica de Gipuzkoa,University of Basque Country, UPV/EH;

    Health Research Institute, BIODONOSTIA,University of Basque Country, UPV/EH;

    CIBER Epidemiología y Salud Pública (CIBERESP),IUOPA-Preventive Medicine and Public Health Area, Department of Medicine, University of Oviedo;

    ISGlobal, Barcelona Institute for Global Health - Campus MAR,Universitat Pompeu Fabra (UPF),CIBER Epidemiología y Salud Pública (CIBERESP),IMIM (Hospital del Mar Medical Research Institute);

    ISGlobal, Barcelona Institute for Global Health - Campus MAR,Universitat Pompeu Fabra (UPF),CIBER Epidemiología y Salud Pública (CIBERESP),IMIM (Hospital del Mar Medical Research Institute);

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  • 正文语种 eng
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  • 关键词

    Indoor exposure; Microbial load; Green space; Grey space; Asthma; Allergic rhinitis;

    机译：室内暴露;微生物负荷;绿色空间;灰色空间;哮喘;过敏性鼻炎;

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