...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental research >Maternal exposure to ozone and PM_(2.5) and the prevalence of orofacial clefts in four U.S. states
【24h】

Maternal exposure to ozone and PM_(2.5) and the prevalence of orofacial clefts in four U.S. states

机译：美国四个州的孕产妇暴露于臭氧和PM_（2.5）以及口颌裂的患病率

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: While there is some evidence that maternal exposure to ambient air pollution is associated with orofacial clefts in offspring, the epidemiologic studies have been largely equivocal. We evaluated whether maternal exposure to elevated county-level ambient fine particulate matter with aerodynamic diameter s2.5 μm (PM2.5) and ozone during early gestation was associated with a higher prevalence of orofacial clefts. Methods: Birth data consisting of 4.7 million births from 2001 to 2007 were obtained from National Birth Defects Prevention Network for four states — Arizona, Florida, New York (excluding New York City), and Texas. The air pollution exposure assessment for gestational weeks 5-10 was based on county-level average concentrations of PM_(2.5) and ozone data generated using a Bayesian fusion model available through CDC's Environmental Public Health Tracking Network. Two outcomes were analyzed separately: cleft lip with or without cleft palate, cleft palate alone. In logistic regression analyses, we adjusted for factors that were suspected confounders or modifiers of the association between the prevalence of orofacial clefts and air pollution, i.e., infant sex, race-ethnicity, maternal education, smoking status during pregnancy, whether this was mother's first baby, maternal age. Results: Each 10 ng/m~3 increase in PM_(2.5) concentration was significantly associated with cleft palate alone (OR =1.43, 95% CI: 1.11-1.86). There was no significant association between PM_(2.5) concentration and cleft lip with or without cleft palate. No associations were observed between ozone exposure and the two outcomes of orofacial clefts. Conclusions: Our study suggests that PM_(2.5) significantly increased the risk of cleft palate alone, but did not change the incidence of cleft lip with or without palate. Ozone levels did not correlate with incidence of orofacial clefts.
机译：背景：虽然有证据表明母亲暴露于环境空气污染与后代的口面部裂口有关，但流行病学研究在很大程度上是模棱两可的。我们评估了孕早期孕产妇暴露于空气动力学直径为s2.5μm（PM2.5）且空气动力学直径为s2.5μm（PM2.5）的高水平县级环境细颗粒物是否与较高的口面部裂隙患病率相关。方法：从2001年至2007年的470万例新生儿的出生数据是从美国四个州的国家出生缺陷预防网络获得的，这四个州分别是亚利桑那州，佛罗里达州，纽约（纽约市除外）和德克萨斯州。妊娠第5-10周的空气污染暴露评估基于县级平均PM_（2.5）浓度和使用CDC环境公共卫生追踪网络提供的贝叶斯融合模型生成的臭氧数据。分别分析了两种结果：唇裂伴或不伴有c裂，仅pa裂。在逻辑回归分析中，我们调整了怀疑是口面部裂隙患病率与空气污染之间的关联的混杂因素或修正因素，例如婴儿性别，种族，孕产妇教育，怀孕期间的吸烟状况，这是否是母亲的首次婴儿，产妇年龄。结果：PM_（2.5）浓度每升高10 ng / m〜3都与单独的c裂显着相关（OR = 1.43，95％CI：1.11-1.86）。 PM_（2.5）浓度与有或没有c裂的唇裂之间无显着关联。没有观察到臭氧暴露与口唇裂的两种结果之间的关联。结论：我们的研究表明，PM_（2.5）显着增加了单独c裂的风险，但并没有改变有或没有pa裂的唇裂的发生率。臭氧水平与口唇裂的发生率无关。

著录项

  • 来源
    《Environmental research》 |2017年第2期|35-40|共6页
  • 作者

    Ying Zhou; Suzanne M. Gilboa; Michele L. Herdt; Philip J. Lupo; W. Dana Flanders; Yang Liu; Mikyong Shin; Mark A. Canfield; Russell S. Kirby;

  • 作者单位

    Environmental Health Tracking Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA;

    Birth Defects Branch, Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA;

    New York State Department of Health, Center for Environmental Health, Albany, NY, USA,State University of New York at Albany, Department of Epidemiology and Biostatistics, Rensselaer, NY, USA;

    Baylor College of Medicine, Department of Pediatrics, Section of Hematology-Oncology, Houston, TX, USA;

    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA;

    Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA;

    Environmental Health Tracking Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA;

    Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, USA;

    Department of Community and Family Health, College of Public Health, University of South Florida, Tampa, FL, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    PM_(2.5); Ozone; Air pollution; Cleft lip; Cleft palate;

    机译：PM（2.5）;臭氧;空气污染;唇裂;C裂;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号