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首页> 外文期刊>Environmental research >Occurrence and prenatal exposure to persistent organic pollutants using meconium in Korea: Feasibility of meconium as a non-invasive human matrix
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Occurrence and prenatal exposure to persistent organic pollutants using meconium in Korea: Feasibility of meconium as a non-invasive human matrix

机译：在韩国，使用粪便的发生和产前暴露于持久性有机污染物的情况：粪便作为非侵入性人类基质的可行性

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摘要

Prenatal exposure to persistent organic pollutants (POPs) is of great concern due to the vulnerability of fetus. Nineteen Polychlorinated biphenyls (PCBs), 18 organochlorine pesticides (OCPs) including DDTs, HCHs, chlordanes, and hexachlorobenzene, and 22 polybrominated diphenyl ethers (PBDEs) were measured in meconium samples from 72 newborn infants using high resolution gas chromatography/ mass spectrometry. The median concentrations (on wet weight basis) of PCBs, OCPs, and PBDEs were 26.8 pg/g, 66.7 pg/g, and 2.32 pg/g, respectively. Highly significant correlations were observed among the compounds of PCBs and OCPs, suggesting their similar sources and kinetic behaviors. BDE 47 had significant correlations with PCBs and OCPs, whereas BDE 209 was not correlated with any of the contaminants due to different exposure sources. The concentrations of p,p'-DDE, β-HCH, and trans-nonaCHL between paired maternal blood-meconium and cord blood-meconium showed significant correlations, while PCBs and PBDEs were not significantly correlated in the paired samples. Maternal age and ge-stational age were demographic parameters affecting POP levels in meconium. Multiple regression analysis showed that the levels of several OCPs in cord and maternal serum were contributing factors governing the levels of these contaminants in meconium. Our results indicate that meconium can be utilized as a human matrix for prenatal exposure to several OCPs.
机译：由于胎儿的脆弱性，产前暴露于持久性有机污染物（POPs）非常令人担忧。使用高分辨率气相色谱/质谱法从72个新生儿的胎粪样品中测量了19种多氯联苯（PCB），18种有机氯农药（OCP），包括DDT，HCH，氯丹和六氯苯，以及22种多溴联苯醚（PBDE）。多氯联苯，OCP和多溴二苯醚的中值浓度（按湿重计）分别为26.8 pg / g，66.7 pg / g和2.32 pg / g。在PCB和OCP的化合物之间观察到高度相关性，表明它们的来源和动力学行为相似。 BDE 47与PCB和OCP具有显着相关性，而BDE 209与暴露于不同来源的任何污染物均不相关。配对母亲血-胎粪和脐血-粪便中p，p'-DDE，β-HCH和反式-nonaCHL的浓度显示出显着的相关性，而配对样品中的PCBs和PBDEs没有显着相关性。产妇年龄和孕育年龄是影响胎粪中POP水平的人口统计学参数。多元回归分析表明，脐带和母体血清中几种OCP的含量是决定胎粪中这些污染物含量的因素。我们的结果表明，胎粪可以用作人类产前暴露于多种OCP的基质。

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  • 来源
    《Environmental research》 |2016年第5期|8-15|共8页
  • 作者

    Yunsun Jeong; Sunggyu Lee; Sunmi Kim; Sung-Deuk Choi; Jeongim Park; Hai-Joong Kim; Jeong Jae Lee; Gyuyeon Choi; Sooran Choi; Sungjoo Kim; Su Young Kim; Young Don Kim; Geumjoon Cho; Eunsook Suh; Sung Koo Kim; So-Hee Eun; Soyong Eom; Seunghyo Kim; Gun-Ha Kim; Sungkyoon Kim; Kyungho Choi; Hyo-Bang Moon;

  • 作者单位

    Department of Marine Sciences and Convergent Technology, Hanyang University, Ansan, Republic of Korea;

    Department of Marine Sciences and Convergent Technology, Hanyang University, Ansan, Republic of Korea;

    School of Public Health, Seoul National University, Seoul, Republic of Korea;

    School of Urban and Environmental Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea;

    College of Natural Sciences, Soonchunhyang University, Asan, Republic of Korea;

    College of Medicine, Korea University, Seoul, Republic of Korea;

    College of Medicine, Soonchunhyang University, Seoul, Republic of Korea;

    College of Medicine, Soonchunhyang University, Seoul, Republic of Korea;

    College of Medicine, Inha University, Incheon, Republic of korea;

    College of Medicine, Hallym University, Seoul, Republic of Korea;

    College of Medicine. Jeju National University, Jeju, Republic of Korea;

    College of Medicine. Jeju National University, Jeju, Republic of Korea;

    College of Medicine, Korea University, Seoul, Republic of Korea;

    College of Medicine, Soonchunhyang University, Seoul, Republic of Korea;

    College of Medicine, Hallym University, Seoul, Republic of Korea;

    College of Medicine, Korea University, Seoul, Republic of Korea;

    College of Medicine, Yonsei University, Seoul, Republic of Korea;

    College of Medicine. Jeju National University, Jeju, Republic of Korea;

    College of Medicine, Korea University, Seoul, Republic of Korea;

    School of Public Health, Seoul National University, Seoul, Republic of Korea;

    School of Public Health, Seoul National University, Seoul, Republic of Korea;

    Department of Marine Sciences and Convergent Technology, Hanyang University, Ansan, Republic of Korea;

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  • 正文语种 eng
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  • 关键词

    Meconium; PBDE; Fetus; Maternal; Cord;

    机译：胎粪;PBDE;胎儿;产妇脐带;

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