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首页> 外文期刊>Environmental research >Residential radon exposure and risk of incident hematologic malignancies in the Cancer Prevention Study-Ⅱ Nutrition Cohort
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Residential radon exposure and risk of incident hematologic malignancies in the Cancer Prevention Study-Ⅱ Nutrition Cohort

机译：癌症预防研究Ⅱ营养队列研究中exposure暴露与血液系统恶性肿瘤发生的风险

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摘要

Dosimetric models show that radon, an established cause of lung cancer, delivers a non-negligible dose of alpha radiation to the bone marrow, as well as to lymphocytes in the tracheobronchial epithelium, and therefore could be related to risk of hematologic cancers. Studies of radon and hematologic cancer risk, however, have produced inconsistent results. To date there is no published prospective, population-based study of residential radon exposure and hematologic malignancy incidence. We used data from the American Cancer Society Cancer Prevention Study-Ⅱ Nutrition Cohort established in 1992, to examine the association between county-level residential radon exposure and risk of hematologic cancer. The analytic cohort included 140,652 participants (66,572 men, 74,080 women) among which 3019 incident hematologic cancer cases (1711 men, 1308 women) were identified during 19 years of follow-up. Cox proportional hazard regression was used to calculate multivariable-adjusted hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for radon exposure and hematologic cancer risk. Women living in counties with the highest mean radon concentrations (＞ 148 Bq/m~3) had a statistically significant higher risk of hematologic cancer compared to those living in counties with the lowest ( ＜ 74 Bq/m~3) radon levels (HR=1.63, 95% CI:1.23-2.18), and there was evidence of a dose-response relationship (HR_(continuous)=1-38, 95% CI:1.15-1.65 per 100 Bq/m~3; p-trend = 0.001). There was no association between county-level radon and hematologic cancer risk among men. The findings of this large, prospective study suggest residential radon may be a risk factor for lymphoid malignancies among women. Further study is needed to confirm these findings.
机译：剂量学模型显示ra是肺癌的既定病因，它向骨髓以及气管支气管上皮细胞的淋巴细胞传递不可忽略的剂量的α辐射，因此可能与血液系统癌症的风险有关。但是，对ra气和血液学癌症风险的研究结果却不一致。迄今为止，尚无针对居民ra暴露和血液系统恶性肿瘤发病率的基于人群的前瞻性研究。我们使用了1992年建立的美国癌症协会癌症预防研究Ⅱ营养研究队列的数据，以检验县级居民ra暴露与血液系统癌症风险之间的关系。该分析队列包括140,652名参与者（66,572名男性，74,080名女性），其中在19年的随访期间确定了3019例血液系统癌症事件（1711名男性，1308名女性）。使用Cox比例风险回归计算calculate暴露和血液学癌症风险的多变量调整后的风险比（HRs）和相应的95％置信区间（CIs）。与平均ra浓度最低（＜74 Bq / m〜3）的县相比，生活在平均ra浓度最高（＞ 148 Bq / m〜3）的县的妇女发生血液癌的风险有统计学意义的高= 1.63，95％CI：1.23-2.18），并且存在剂量反应关系的证据（HR_（连续）= 1-38，95％CI：每100 Bq / m〜3：1.15-1.65； p趋势） = 0.001）。县级ra与男性血液学癌症风险之间没有关联。这项大型的前瞻性研究结果表明，居住中的ra可能是女性淋巴恶性肿瘤的危险因素。需要进一步研究以确认这些发现。

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  • 来源
    《Environmental research》 |2016年第7期|46-54|共9页
  • 作者

    Lauren R. Teras; W. Ryan Diver; Michelle C. Turner; Daniel Krewski; Liora Sahar; Elizabeth Ward; Susan M. Gapstur;

  • 作者单位

    Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA;

    Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA;

    Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain ,Universitat Pompeu Fabra (UPF), Barcelona, Spain ,CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain ,McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada;

    McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada ,School of Epidemiology, Public Health and Disease Prevention, University of Ottawa, Ottawa, Ontario, Canada;

    Statistics and Evaluation Center, American Cancer Society, Atlanta, GA, USA;

    Intramural Research, American Cancer Society, Atlanta, GA, USA;

    Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Radon; Lymphoma; Lymphoid malignancies; Prospective;

    机译：氡;淋巴瘤淋巴恶性肿瘤;预期;

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