...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental research >Feasibility and informative value of environmental sample collection in the National Children's Vanguard Study
【24h】

Feasibility and informative value of environmental sample collection in the National Children's Vanguard Study

机译：在国家儿童先锋研究中收集环境样本的可行性和信息价值

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Birth cohort studies provide the opportunity to advance understanding of the impact of environmental factors on childhood health and development through prospective collection of environmental samples. Methods: We evaluated the feasibility and informative value of the environmental sample collection methodology in the initial pilot phase of the National Children's Study, a planned US. environmental birth cohort study. Environmental samples were collected from January 2009-September 2010 at up to three home visits: pre-pregnancy (n=306), pregnancy (n=807), and 6-months postnatal (n = 117). Collections included air for particulate matter ＜ 2.5 μm (PM_(2.5)), nitrogen dioxide, ozone, volatile organic compounds (VOCs), and carbonyls; vacuum dust for allergens/endotoxin; water for VOCs, trihalo-methanes (THMs), and haloacetic acids (HAAs); and wipe samples for pesticides, semi-volatile organics, and metals. We characterized feasibility using sample collection rates and times and informative value using analyte detection frequencies (DF). Results: Among the 1230 home visits, environmental sample collection rates were high across all sample types (mean=89%); all samples except the air PM2.5 samples had collection times ＜ 30 min. Informative value was low for water VOCs (median DF=0%) and pesticide floor wipes (median DF=5%). Informative value was moderate for air samples (median DF=35%) and high for water THMs and HAAs (median DF=91% and 75%, respectively). Conclusions: Though collection of environmental samples was feasible, some samples (e.g., wipe pesticides and water VOCs) yielded limited information. These results can be used in conjunction with other study design considerations, such as target population size and hypotheses of interest, to inform the method selection of future environmental health birth cohort studies.
机译：背景：出生队列研究提供了机会，可以通过前瞻性收集环境样本来加深对环境因素对儿童健康和发育的影响的了解。方法：我们在计划中的美国国家儿童研究的初始试点阶段评估了环境样品收集方法的可行性和信息价值。环境出生队列研究。从2009年1月至2010年9月在多达三次的家庭访问中收集了环境样本：怀孕前（n = 306），怀孕（n = 807）和产后6个月（n = 117）。收集的气体包括＜2.5μm（PM_（2.5））的颗粒物空气，二氧化氮，臭氧，挥发性有机化合物（VOC）和羰基。真空粉尘，用于过敏原/内毒素；用于挥发性有机化合物，三卤甲烷（THM）和卤乙酸（HAAs）的水；擦拭农药，半挥发性有机物和金属的样品。我们使用样品收集速率和时间来确定可行性，并使用分析物检测频率（DF）来提供有价值的信息。结果：在1230次家访中，所有样本类型的环境样本收集率均很高（平均= 89％）；除空气PM2.5样品外，所有样品的采集时间均＜30分钟。水中挥发性有机化合物（中位数DF = 0％）和农药地板湿巾（中位数DF = 5％）的信息价值低。空气样品的信息量中等（DF的中位数为35％），水THMs和HAA的信息量较高（DF的中位数分别为91％和75％）。结论：尽管收集环境样品是可行的，但一些样品（例如擦拭农药和水VOC）产生的信息有限。这些结果可以与其他研究设计考虑因素一起使用，例如目标人群规模和感兴趣的假设，以为未来环境健康出生队列研究的方法选择提供依据。

著录项

  • 来源
    《Environmental research》 |2015年第7期|345-353|共9页
  • 作者

    Elizabeth Barksdale Boyle; Nicole C. Deziel; Bonny L. Specker; Scott Collingwood; Clifford P. Weisel; David J. Wright; Michael Dellarco;

  • 作者单位

    Westat, 1600 Research Blvd. Rockville, MD, United States,Board on Environmental Studies and Toxicology, National Research Council of The National Academy of Sciences, 500 Fifth Street NW (618), Washington D.C. 20001, United States;

    Yale University School of Public Health, Department of Environmental Health Sciences, New Haven, CT, United States;

    South Dakota State University, Ethel Austin Martin Program in Human Nutrition, Brookings, SD, United States;

    University of Utah, Department of Pediatrics, Salt Lake City, United States;

    Rutgers University, Environmental & Occupational Health Science Institute (EOHSI), Piscataway, NJ, United States;

    Westat, 1600 Research Blvd. Rockville, MD, United States;

    Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Birth cohort study; Air samples; Water samples; Wipe samples; National Children's Study;

    机译：出生队列研究;空气样本;水样;擦拭样品;全国儿童研究;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号