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首页> 外文期刊>Environmental research >Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries
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Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries

机译：解释COPHES / DEMOCOPHES两个项目的生物标志物数据：使用外部暴露数据了解国家之间的生物标志物差异

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摘要

In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed the first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother-child pairs, individual lifestyle data were collected and cadmium, cotinine and certain phthalate metabolites were measured in urine. Total mercury was determined in hair samples. While the main goal of the COPHES/DEMOCOPHES twin projects was to develop and test harmonized protocols and procedures, the goal of the current paper is to investigate whether the observed differences in biomarker values among the countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality and lifestyle. In general, 13 countries having implemented DEMOCOPHES provided high-quality data from external sources that were relevant for interpretation purposes. However, some data were not available for reporting or were not in line with predefined specifications. Therefore, only part of the external information could be included in the statistical analyses. Nonetheless, there was a highly significant correlation between national levels of fish consumption and mercury in hair, the strength of antismoking legislation was significantly related to urinary cotinine levels, and we were able to show indications that also urinary cadmium levels were associated with environmental quality and food quality. These results again show the potential of biomonitoring data to provide added value for (the evaluation of) evidence-informed policy making.
机译：在2011年和2012年，COPHES / DEMOCOPHES双重项目在17个欧洲国家进行了有史以来第一次统一的人类生物监测调查。在1800多个母子对中，收集了个人生活方式数据，并测量了尿液中的镉，可替宁和某些邻苯二甲酸酯代谢物。测定头发样本中的总汞。虽然COPHES / DEMOCOPHES双子项目的主要目标是开发和测试统一的规程和程序，但本文件的目的是调查是否可以使用外部数据库中的信息来解释观察到的实施DEMOCOPHES的国家之间生物标志物价值的差异。环境质量和生活方式。总体而言，已经实施了DEMOCOPHES的13个国家/地区从外部来源提供了与口译目的相关的高质量数据。但是，某些数据不可用于报告或与预定义规范不符。因此，只有部分外部信息可以包括在统计分析中。尽管如此，国家鱼类消费量与头发中的汞含量之间存在高度显着的相关性，反吸烟立法的力度与尿中可替宁水平显着相关，并且我们能够表明有迹象表明尿中镉的含量也与环境质量有关。食物品质。这些结果再次表明，生物监测数据有潜力为循证决策制定（评估）提供附加价值。

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  • 来源
    《Environmental research》 |2015年第8期|86-95|共10页
  • 作者

    R. Smolders; E. Den Hond; G. Koppen; E. Govarts; H. Willems; et al;

  • 作者单位

    Flemish Institute of Technological Research (VITO), Environmental Risks and Health Unit, Boeretang 200, 2400 Mol, Belgium;

    Flemish Institute of Technological Research (VITO), Environmental Risks and Health Unit, Boeretang 200, 2400 Mol, Belgium;

    Flemish Institute of Technological Research (VITO), Environmental Risks and Health Unit, Boeretang 200, 2400 Mol, Belgium;

    Flemish Institute of Technological Research (VITO), Environmental Risks and Health Unit, Boeretang 200, 2400 Mol, Belgium;

    Flemish Institute of Technological Research (VITO), Environmental Risks and Health Unit, Boeretang 200, 2400 Mol, Belgium;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Human biomonitoring; Interpretation; COPHES; DEMOCOPHES; External exposure data;

    机译：人体生物监测;解释;COPHES;人口;外部暴露数据;

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