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首页> 外文期刊>Environmental research >Growth in Inuit children exposed to polychlorinated biphenyls and lead during fetal development and childhood
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Growth in Inuit children exposed to polychlorinated biphenyls and lead during fetal development and childhood

机译：因纽特人儿童在胎儿发育和童年时期接触多氯联苯和铅的生长

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摘要

Background: Because of their geographical location and traditional lifestyle, Canadian Inuit children are highly exposed to polychlorinated biphenyls (PCBs) and lead (Pb), environmental contaminants that are thought to affect fetal and child growth. We examined the associations of these exposures with the fetal and postnatal growth of Inuit children. Methods: We conducted a prospective cohort study among Inuit from Nunavik (Arctic Quebec). Mothers were recruited at their first prenatal visit; children (n=290) were evaluated at birth and at 8-14 years of age. Concentrations of PCB 153 and Pb were determined in umbilical cord and child blood. Weight, height and head circumference were measured at birth and during childhood. Results: Cord blood PCB 153 concentrations were not associated with anthropometric measurements at birth or school age, but child blood PCB 153 concentrations were associated with reduced weight, height and head circumference during childhood. There was no association between cord Pb levels and anthropometric outcomes at birth, but cord blood Pb was related to smaller height and shows a tendency of a smaller head circumference during childhood. Interpretation: Our results suggest that chronic exposure to PCBs during childhood is negatively associated with skeletal growth and weight, while prenatal Pb exposure is related to reduced growth during childhood. This study is the first to link prenatal Pb exposure to poorer growth in school-age children.
机译：背景：由于其地理位置和传统生活方式，加拿大因纽特人儿童高度暴露于多氯联苯（PCBs）和铅（Pb）等环境污染物，被认为会影响胎儿和儿童的成长。我们检查了这些暴露与因纽特人儿童的胎儿和产后生长的关系。方法：我们在努纳维克（魁北克北极）的因纽特人中进行了一项前瞻性队列研究。母亲是在第一次产前检查时招募的。在出生时和8-14岁之间对儿童（n = 290）进行了评估。测定脐带血和儿童血液中PCB 153和Pb的浓度。在出生时和儿童时期测量体重，身高和头围。结果：脐带血PCB 153的浓度与出生或学龄时的人体测量学无关，但儿童血液PCB 153的浓度与儿童时期体重，身高和头围的减少有关。出生时脐带血铅水平与人体测量结果之间没有关联，但是脐带血铅与身高较小有关，并显示出儿童时期头围较小的趋势。解释：我们的结果表明，儿童时期长期接触PCBs与骨骼生长和体重负相关，而产前Pb暴露与儿童时期生长下降有关。这项研究是第一个将产前铅暴露与学龄儿童生长不良联系起来的研究。

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  • 来源
    《Environmental research》 |2014年第10期|17-23|共7页
  • 作者

    Renee Dallaire; Eric Dewailly; Pierre Ayotte; Nadine Forget-Dubois; Sandra W. Jacobson; Joseph L. Jacobson; Gina Muckle;

  • 作者单位

    Ecole de psychologie, Universite Laval and Centre de recherche du CHU de Quebec, Quebec City, QC, Canada;

    Departement de medecine sociale et preventive, Universite Laval and Centre de recherche du CHU de Quebec, Quebec City, QC, Canada;

    Departement de medecine sociale et preventive, Universite Laval and Centre de recherche du CHU de Quebec, Quebec City, QC, Canada;

    Ecole de psychologie, Universite Laval and Centre de recherche du CHU de Quebec, Quebec City, QC, Canada;

    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA;

    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA;

    Ecole de psychologie, Universite Laval and Centre de recherche du CHU de Quebec, Quebec City, QC, Canada,Centre de recherche du CHU de Quebec, 2875 Boul. Laurier, Bureau 600, Quebec (QC), Canada, G1V 2M2;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Fetal growth; Child growth; Polychlorinated biphenyls; Lead; Inuit;

    机译：胎儿生长;儿童成长;多氯联苯;铅;因纽特人;

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