...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental research >Persistent organic pollutants are related to the change in circulating lipid levels during a 5 year follow-up
【24h】

Persistent organic pollutants are related to the change in circulating lipid levels during a 5 year follow-up

机译：持续的有机污染物与5年随访期间循环脂质水平的变化有关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

When reporting circulating levels of persistent organic pollutants (POPs), usually lipid-normalized values are given. However, animal experiments and some human data indicate that exposure to POPs may change lipid values. The aim of the present study is to investigate if POP levels can predict future changes in levels of circulating lipids. In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, lipids were measured at age 70 and at age 75 in 598 subjects without lipid-lowering medication. Twenty-three different POPs, including 16 polychlorinated biphenyls (PCBs), five organochlorine pesticides, one dioxin (OCDD) and one flame retardant brominated compound (BDE47) were analyzed by high-resolution chromatography coupled to high-resolution mass spectrometry (HRGC/HRMS) at age 70. Strong relationships were seen among the baseline levels of the non-dioxin-like PCBs 194, 206 and 209 and the degree of increase in total serum cholesterol and LDL-cholesterol during the 5 year follow-up. These relationships were generally stronger when lipid-normalized levels were used compared to wet-weight based levels. On the contrary, for two of the pesticides, hexachlorobenzene and trans-nonachlordane, levels were inversely related to the change in LDL-cholesterol, with strongest associations found using wet-weight based levels. PCBs 194, 206 and 209 were inversely related to the change in HDL-cholesterol, in particular for wet-weight based levels. However, these relationships were only significant for wet-weight PCB 194 following adjustment for multiple testing. None of the POPs was related to the change in serum triglycerides. When investigating the association between the change in total serum cholesterol and LDL-cholesterol across different categories of change in BMI, we noted robust results especially in the group with stable BMI, suggesting that the observed relationships were not due to fluctuations in BMI over time. In conclusion, POPs are related to the change in lipids over time, especially LDL-cholesterol. This may explain why POP exposure previously has been linked to atherosclerosis and cardiovascular disease.
机译：报告持久性有机污染物（POP）的循环水平时，通常会给出脂质标准化值。但是，动物实验和一些人类数据表明，暴露于POPs可能会改变脂质值。本研究的目的是调查POP含量是否可以预测未来血脂水平的变化。在基于人群的乌普萨拉老年人血管前瞻性调查（PIVUS）研究中，在没有降脂药物的598名受试者中测量了70岁和75岁时的脂质。通过高分辨率色谱-高分辨率质谱法（HRGC / HRMS）分析了23种不同的POP，包括16种多氯联苯（PCB），5种有机氯农药，一种二恶英（OCDD）和一种阻燃溴化化合物（BDE47）。 ）年龄为70岁。在5年的随访期间，非二恶英样多氯联苯194、206和209的基线水平与总血清胆固醇和LDL-胆固醇升高的程度之间存在密切关系。与基于湿重的水平相比，使用脂质归一化水平时，这些关系通常更强。相反，对于其中的两种农药，六氯苯和反式九氯丹，其含量与LDL-胆固醇的变化呈负相关，而以湿重为基准的含量之间的关联最强。 PCB 194、206和209与HDL胆固醇的变化呈负相关，特别是基于湿重的水平。但是，这些关系仅在调整多次测试后对湿重PCB 194才有意义。持久性有机污染物均与血清甘油三酸酯的变化无关。在调查不同BMI变化类别中的总血清胆固醇和LDL-胆固醇之间的关联时，我们注意到了强劲的结果，尤其是在BMI稳定的人群中，这表明观察到的关系不是由于BMI随时间的波动而引起的。总之，POPs与脂质（尤其是LDL-胆固醇）随时间的变化有关。这可以解释为什么以前将POP暴露与动脉粥样硬化和心血管疾病联系在一起。

著录项

  • 来源
    《Environmental research》 |2014年第10期|190-197|共8页
  • 作者

    Johanna Penell; Lars Lind; Samira Salihovic; Bert van Bavel; P. Monica Lind;

  • 作者单位

    Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, SE-751 85 Uppsala, Sweden;

    Department of Medical Sciences, Cardiovascular epidemiology, Uppsala University, Uppsala, Sweden;

    MTM Research Centre, School of Science and Technology, OErebro University, OErebro, Sweden;

    MTM Research Centre, School of Science and Technology, OErebro University, OErebro, Sweden;

    Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, SE-751 85 Uppsala, Sweden;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Persistent organic pollutants; Lipids; Lipid-normalized; Wet-weight; Prospective;

    机译：持久性有机污染物;脂质;脂质归一化;湿重预期;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号