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首页> 外文期刊>Environmental research >Polymorphisms in DNA repair genes XRCC1 and XRCC3, occupational exposure to arsenic and sunlight, and the risk of non-melanoma skin cancer in a European case-control study
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Polymorphisms in DNA repair genes XRCC1 and XRCC3, occupational exposure to arsenic and sunlight, and the risk of non-melanoma skin cancer in a European case-control study

机译:欧洲病例对照研究中,DNA修复基因XRCC1和XRCC3的多态性,职业暴露于砷和阳光下以及非黑素瘤皮肤癌的风险

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摘要

X-ray repair cross-complementing group 1 (XRCC1) and group 3 (XRCC3) polymorphisms are relatively frequent in Caucasian populations and may have implications in skin cancer modulation. A few studies have evaluated their association with non-melanoma skin cancer (NMSC), but the results are inconsistent. In the current study, we aim to assess the impact of XRCC1 R399Qand XRCC3 T241M polymorphisms on the risk of NMSC associated with sunlight and arsenic exposure. Study participants consist of 618 new cases of NMSC and 527 hospital-based controls frequency matched on age, sex, and county of residence from Hungary, Romania, and Slovakia. Adjusted effects are estimated using multivariable logistic regression. The results indicate an increased risk of squamous cell carcinoma (SCC) for the homozygous variant genotype of XRCC1 R399Q (OR 2.53, 95% CI 1.14-5.65) and a protective effect against basal cell carcinoma (BCC) for the homozygous variant genotype of XRCC3 T241M (OR 0.61, 95% CI 0.41-0.92), compared with the respective homozygous common genotypes. Significant interactions are detected between XRCC3 T241M and sunlight exposure at work, and between XRCC3 T241M and exposure to arsenic in drinking water (p-value for interaction < 0.10). In conclusion, the current study demonstrates that polymorphisms in XRCC genes may modify the associations between skin cancer risk and exposure to sunlight or arsenic. Given the high prevalence of genetic polymorphisms modifying the association between exposure to environmental carcinogens and NMSC, these results are of substantial relevance to public health.
机译:X射线修复交叉互补的第1组(XRCC1)和第3组(XRCC3)多态性在白种人人群中相对频繁,并且可能对皮肤癌的调节有影响。一些研究评估了它们与非黑色素瘤皮肤癌(NMSC)的关联,但结果不一致。在当前的研究中,我们旨在评估XRCC1 R399Q和XRCC3 T241M多态性对与阳光和砷暴露相关的NMSC风险的影响。研究参与者包括618例新的NMSC病例和527例基于医院的对照频率,这些频率与年龄,性别和匈牙利,罗马尼亚和斯洛伐克的居住县相匹配。调整后的效果使用多变量逻辑回归进行估算。结果表明,XRCC1 R399Q(OR 2.53,95%CI 1.14-5.65)的纯合子变异基因型的鳞状细胞癌(SCC)风险增加以及XRCC3的纯合子变异基因型的基底细胞癌(BCC)的保护作用T241M(OR 0.61,95%CI 0.41-0.92),与各自纯合的常见基因型相比。 XRCC3 T241M与工作中的日光暴露之间以及XRCC3 T241M与饮用水中的砷暴露之间存在显着的相互作用(相互作用的p值<0.10)。总之,当前的研究表明,XRCC基因中的多态性可能会改变皮肤癌风险与暴露于阳光或砷之间的关联。鉴于遗传多态性改变了暴露于环境致癌物和NMSC之间的关联的普遍性,这些结果与公共卫生具有重大关联。

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  • 来源
    《Environmental research》 |2014年第10期|382-389|共8页
  • 作者单位

    Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA,Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA,Institute for Health and the Environment, University at Albany, State University of New York, Rensselaer, NY, USA;

    Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA,Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA;

    Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA,Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA,Institute for Health and the Environment, University at Albany, State University of New York, Rensselaer, NY, USA;

    Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA,New York State Cancer Registry, New York State Department of Health, Albany, NY, USA;

    Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, 1 University Place, Rensselaer, NY 12144, USA,Institute for Health and the Environment, University at Albany, State University of New York, Rensselaer, NY, USA;

    Institute for Health and the Environment, University at Albany, State University of New York, Rensselaer, NY, USA,Department of Educational and Counseling Psychology, School of Education, University at Albany, State University of New York, Albany, NY, USA;

    Health Department, Environmental Health Center, Cluj-Napoca, Romania;

    Department of Environmental Epidemiology, National Institute of Environmental Health, Budapest, Hungary;

    Department of Environmental Health, Regional Authority of Public Health, Banska Bystrica, Slovakia;

    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;

    Department of Social and Environmental Health Research, Public Health, London School of Hygiene and Tropical Medicine, London, UK,Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, UK;

    Institut fuer Chemie-Analytische Chemie, Karl-Franzens-Universitaet, Graz, Austria;

    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany;

    Department of Social and Environmental Health Research, Public Health, London School of Hygiene and Tropical Medicine, London, UK;

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  • 正文语种 eng
  • 中图分类
  • 关键词

    Non-melanoma skin cancer; DNA repair polymorphisms; Exposure; Arsenic; Sunlight;

    机译:非黑色素瘤皮肤癌;DNA修复多态性;接触;砷;阳光;

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