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The impact of decreases in air temperature and increases in ozone on markers of endothelial function in individuals having type-2 diabetes

机译：气温下降和臭氧增加对2型糖尿病患者内皮功能标志物的影响

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摘要

Several studies have reported an association between air pollution and endothelial dysfunction, especially in individuals having diabetes. However, very few studies have examined the impact of air temperature on endothelial function. The objective of this analysis was to investigate short-term effects of temperature and ozone on endothelial function in individuals having diabetes. Moreover, we investigated interactive effects between air temperature and air pollution on markers of endothelial function. Between November 2004 and December 2005 flow-mediated dilatation (FMD), nitroglycerin-mediated dilatation (NTGMD) and several blood markers representing endothelial function were measured using brachial artery ultrasound on four consecutive days in 22 individuals with type-2 diabetes mellitus in Chapel Hill, North Carolina (USA). Daily measurements of meteorological parameters, ozone and particulars matter with an aerodynamic diameter ≤ 2.5 μm (PM_(2.5)) were obtained from fixed monitoring sites. We used additive mixed-models adjusting for time trend, day of the week, relative humidity and barometric pressure to assess temperature and ozone associations with endothelial function. A 1 ℃ decrease in the 24-h temperature average was associated with a decrease in mean FMD on the same day (-2.2% (95%-confidence interval:[-4.7;03%])) and with a delay of one and four days. A temperature decrement also led to an immediate (-1.7%[ -3.3; -0.04]) decrease in NTGMD. Moreover, we observed an immediate (-14.6%[ -26.3; -2.9%]) and a one day delayed (-13.5% [-27.0; 0.04%]) decrease in FMD in association with a 0.01 ppm increase in the maximum 8-h moving average of ozone. Temperature effects on FMD strengthened when PM_(2.5) and ozone concentrations were high. The associations were similar during winter and summer. We detected an association between temperature decreases and ozone increases on endothelial dysfunction in individuals having diabetes. We conclude that endothelial dysfunction might be a possible mechanism explaining cardiovascular events in association with environmental stimuli.
机译：几项研究报告了空气污染与内皮功能障碍之间的关联，尤其是在患有糖尿病的个体中。但是，很少有研究检查空气温度对内皮功能的影响。该分析的目的是研究温度和臭氧对糖尿病患者内皮功能的短期影响。此外，我们研究了空气温度和空气污染之间对内皮功能标记物的相互作用的影响。在2004年11月至2005年12月之间，连续22天使用肱动脉超声在教堂山（Chapel Hill）的22位2型糖尿病患者中，连续测量了血流介导的扩张（FMD），硝酸甘油介导的扩张（NTGMD）和几种代表内皮功能的血液标志物，北卡罗来纳州（美国）。每天从固定的监测点获得空气动力学直径≤2.5μm（PM_（2.5））的气象参数，臭氧和特殊物质的每日测量值。我们使用添加剂混合模型调整时间趋势，星期几，相对湿度和大气压力，以评估温度和臭氧与内皮功能的关系。 24小时平均温度降低1℃会导致同一天的平均FMD降低（-2.2％（95％置信区间：[-4.7; 03％]），延迟时间为1和四天。温度下降还导致NTGMD立即下降（-1.7％[-3.3; -0.04]）。此外，我们观察到FMD立即下降（-14.6％[-26.3; -2.9％]）和延迟一天（-13.5％[-27.0; 0.04％]），而最大值8增加0.01 ppm -h臭氧的移动平均值。当PM_（2.5）和臭氧浓度较高时，对口蹄疫的温度效应增强。冬季和夏季的关联性相似。我们发现糖尿病患者的内皮功能障碍中温度降低和臭氧增加之间存在关联。我们得出结论，内皮功能障碍可能是解释心血管事件与环境刺激有关的可能机制。

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  • 来源
    《Environmental research》 |2014年第10期|331-338|共8页
  • 作者

    Stefanie Lanzinger; Susanne Breitner; Lucas Neas; Wayne Cascio; David Diaz-Sanchez; Alan Hinderliter; Annette Peters; Robert B. Devlin; Alexandra Schneider;

  • 作者单位

    Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology Ⅱ, Neuherberg, Germany;

    Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology Ⅱ, Neuherberg, Germany;

    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC, USA;

    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC, USA;

    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC, USA;

    University of North Carolina, School of Medicine, Chapel Hill, NC, USA;

    Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology Ⅱ, Neuherberg, Germany;

    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC, USA;

    Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology Ⅱ, Neuherberg, Germany;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Endothelial dysfunction; Temperature; Ozone; Particulate matter; Interactive effects; Epidemiology;

    机译：内皮功能障碍;温度;臭氧;颗粒物;互动效果;流行病学;

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