...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental research >Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community
【24h】

Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community

机译：生活在农业社区中的妇女和新生儿的血液和尿液中的有机磷农药水平

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Organophosphate pesticides are widely used and recent studies suggest associations of in utero exposures with adverse birth outcomes and neurodevelopment. Few studies have characterized organophosphate pesticides in human plasma or established how these levels correlate to urinary measurements. We measured organophosphate pesticide metabolites in maternal urine and chlorpyrifos and diazinon in maternal and cord plasma of subjects living in an agricultural area to compare levels in two different biological matrices. We also determined paraoxonase 1 (PON1) genotypes (PON1 _(192) and PON1_(_108)) and PONJ substrate-specific activities in mothers and their newborns to examine whether PONJ may affect organophosphate pesticide measurements in blood and urine. Chlorpyrifos levels in plasma ranged from 0-1726 ng/mL and non-zero levels were measured in 70.5% and 87.5% of maternal and cord samples, respectively. Diazinon levels were lower (0-0.5 ng/mL); non-zero levels were found in 33.3% of maternal plasma and 47.3% of cord plasma. Significant associations between organophosphate pesticide levels in blood and metabolite levels in urine were limited to models adjusting for PONJ levels. Increased maternal PONJ levels were associated with decreased odds of chlorpyrifos and diazinon detection (odds ratio(OR): 0.56 and 0.75, respectively). Blood organophosphate pesticide levels of study participants were similar in mothers and newborns and slightly higher than those reported in other populations. However, compared to their mothers, newborns have much lower quantities of the detoxifying PONJ enzyme suggesting that infants may be especially vulnerable to organophosphate pesticide exposures.
机译：有机磷酸酯农药已被广泛使用，最近的研究表明子宫内暴露与不良的出生结局和神经发育有关。很少有研究对人血浆中的有机磷酸酯农药进行鉴定，或确定这些水平与尿液测量值之间的关系。我们测量了生活在农业地区的受试者的母体尿液中的有机磷酸盐农药代谢产物以及毒死rif和地嗪酮的含量，以比较两种不同生物基质中的水平。我们还确定了母亲及其新生儿的对氧磷酶1（PON1）基因型（PON1_（192）和PON1 _（_ 108））和PONJ底物特异性活性，以检查PONJ是否会影响血液和尿液中有机磷农药的测定。血浆中毒死rif的含量范围为0-1726 ng / mL，在母体和脐带样品中分别测得的毒死rif含量为70.5％和87.5％。二嗪农含量较低（0-0.5 ng / mL）；非血浆水平在母体血浆中占33.3％，在脐带血浆中占47.3％。血液中有机磷农药水平与尿中代谢物水平之间的显着关联仅限于针对PONJ水平进行调整的模型。孕妇PONJ水平升高与毒死rif和二嗪农检出几率降低相关（OR（比值比）：0.56和0.75）。研究参与者的血液中有机磷农药水平在母亲和新生儿中相似，并且略高于其他人群中报告的水平。但是，与母亲相比，新生儿的排毒PONJ酶含量要低得多，这表明婴儿可能特别容易受到有机磷酸盐农药的暴露。

著录项

  • 来源
    《Environmental research》 |2012年第8期|p.8-16|共9页
  • 作者

    Karen Huen; Asa Bradman; Kim Harley; Paul Yousefi; Dana Boyd Barr; Brenda Eskenazi; Nina Holland;

  • 作者单位

    Center for Environmental Research and Children's Health, School of Public Health, University of California, Berkeley, 1995 University Avenue Suite 265, Berkeley CA 94720, USA, 1301 S. 46th Street, Building 112, Richmond, CA 94804;

    Center for Environmental Research and Children's Health, School of Public Health, University of California, Berkeley, 1995 University Avenue Suite 265, Berkeley CA 94720, USA;

    Center for Environmental Research and Children's Health, School of Public Health, University of California, Berkeley, 1995 University Avenue Suite 265, Berkeley CA 94720, USA;

    Center for Environmental Research and Children's Health, School of Public Health, University of California, Berkeley, 1995 University Avenue Suite 265, Berkeley CA 94720, USA;

    Department of Environmental Health, Rollins School of Public Health, Emory University, 1578 Clifton Road, NE, Claudia Nance Rollins Bldg, Room 2007, Atlanta CA 30322, USA;

    Center for Environmental Research and Children's Health, School of Public Health, University of California, Berkeley, 1995 University Avenue Suite 265, Berkeley CA 94720, USA;

    Center for Environmental Research and Children's Health, School of Public Health, University of California, Berkeley, 1995 University Avenue Suite 265, Berkeley CA 94720, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    paraoxonase; organophosphate pesticides; biomarkers; cord blood; maternal blood; urinary metabolites;

    机译：对氧磷酶有机磷酸盐农药;生物标志物脐带血;母血尿代谢物;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号