...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental research >Maternal smoking during pregnancy, polymorphic CYP1A1 and GSTM1, and lung-function measures in urban family children
【24h】

Maternal smoking during pregnancy, polymorphic CYP1A1 and GSTM1, and lung-function measures in urban family children

机译：怀孕期间的孕妇吸烟，CYP1A1和GSTM1多态性以及城市家庭儿童的肺功能测定

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: Understanding the interplay between genes and in-utero tobacco exposure in affecting child lung development is of great significance. In this study, we tested the hypothesis that tobacco-related lung-function reduction in children differs by maternal polymorphic genes Cytochrome P450 1A1 (CYP1A1) and Clutathione S-transferase Mu 1 (GSTM1). Materials and methods: Data were collected among 370 children (6-10 years old, 81.6% African-Americans) and their biological mothers visiting a large children's hospital. Study hypotheses were tested using multiple regression method. Results: Among the study sample, 143 mothers smoked throughout pregnancy and 72 smoked on a daily basis. Spirometric measures (mean + SD) included were: forced vital capacity (FVC)= 1635+ 431 mL forced expiratory volume in the first 1 s (FEV,) = 1440 + 360 mL, percent FEV_1/FVC ratio=89 + 12, and forced expiratory flow between the 25% and 75% of FVC (FEF_(25-75))= 1745 + 603 mL In addition to a tobacco effect on FVC (-131 mL 95% CI: -245, -17) and FEV,/FVC ratio (42, 95% CI: 1, 83), regression analysis controlling for covariates indicated that for the subsample of children whose mothers were CYP1A1~*2A homozygous, maternal daily smoking was associated with -734 mL (95% CI: -1206, -262) reductions in FEV_1 and -825 mL (95% CI: -909, -795) reductions in FVC; reduced smoking was still associated with -590 mL (95% CI: -629, -551) reductions in FVC. For children of mothers with GSTM1 deletion, persistent daily smoking was associated with -176 mL (95% CI: -305, -47) reductions in FVC. Discussion and conclusions: Maternal smoking during pregnancy was significantly associated with lung-function reduction in children, particularly for those whose mothers possessed the polymorphic CYP1A1~*2A and GSTM1 deletion.
机译：目的：了解基因与宫内烟草暴露之间的相互作用对影响儿童肺部发育具有重要意义。在这项研究中，我们检验了以下假说，即儿童中与烟草有关的肺功能降低因母体多态基因Cytochrome P450 1A1（CYP1A1）和Clutathione S-transferase Mu 1（GSTM1）而异。材料和方法：收集了370名儿童（6-10岁，占81.6％的非洲裔美国人）及其亲生母亲在一家大型儿童医院就诊的数据。研究假设使用多元回归方法进行检验。结果：在研究样本中，有143位母亲在整个怀孕期间吸烟，每天有72位吸烟者。包括的肺活量测量（平均值+ SD）为：强制肺活量（FVC）= 1635+ 431 mL前1 s（FEV，）的强制呼气量= 1440 + 360 mL，FEV_1 / FVC的百分比= 89 + 12，以及FVC（FEF_（25-75））的25％至75％之间的强制呼气流量= 1745 + 603 mL除了烟草对FVC（-131 mL 95％CI：-245，-17）和FEV的影响外， / FVC比率（42，95％CI：1，83），控制协变量的回归分析显示，对于母亲为CYP1A1〜* 2A纯合子代的儿童子样本，母亲每天吸烟与-734 mL相关（95％CI： FEV_1减少-1206，-262），FVC减少-825 mL（95％CI：-909，-795）;吸烟减少仍与FVC降低-590 mL（95％CI：-629，-551）有关。对于患有GSTM1缺失的母亲的孩子，每天持续吸烟与FVC降低-176 mL（95％CI：-305，-47）有关。讨论与结论：孕妇孕期吸烟与儿童肺功能下降显着相关，特别是对于那些母亲具有CYP1A1〜* 2A多态性和GSTM1缺失的母亲。

著录项

  • 来源
    《Environmental research》 |2011年第8期|p.1215-1221|共7页
  • 作者

    Xinguang Chen; Ibrahim Abdulhamid; Kimberley Woodcraft;

  • 作者单位

    The Adams Ann Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA,Prevention Research Center, Wayne State University Department of Pediatrics, 4707 St. Antoine, Hutzel Building W534, Detroit, MI 48201, USA;

    The Adams Ann Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA;

    Henry Ford Health System, Detroit, MI, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    gene-tobacco interaction; lung function; maternal smoking; metabolic genes;

    机译：基因-烟草相互作用肺功能孕妇吸烟;代谢基因;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号