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首页> 外文期刊>Environmental Science & Technology >Contributions of City-Specific Fine Particulate Matter (PM_(2.5)) to Differential In Vitro Oxidative Stress and Toxicity Implications between Beijing and Guangzhou of China
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Contributions of City-Specific Fine Particulate Matter (PM_(2.5)) to Differential In Vitro Oxidative Stress and Toxicity Implications between Beijing and Guangzhou of China

机译：中国北京和广州之间特定城市细颗粒物（PM_（2.5））对体外氧化应激差异和毒性的贡献

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摘要

Growing literature has documented varying toxic potencies of source- or site-specific fine particulate matter (PM2.5), as opposed to the practice that treats particle toxicities as independent of composition given the incomplete understanding of the toxicity of the constituents. Quantifying component-specific contribution is the key to unlocking the geographical disparities of particle toxicity from a mixture perspective. In this study, we performed integrated mixture toxicity experiments and modeling to quantify the contribution of metals and polycyclic aromatic hydrocarbons (PAHs), two default culprit component groups of PM2.5 toxicity, to in vitro oxidative stress caused by wintertime PM2.5 from Beijing and Guangzhou, two megacities in China. PM2.5 from Beijing exhibited greater toxic potencies at equal mass concentrations. The targeted chemical analysis revealed higher burden of metals and PAHs per unit mass of PM2.5 in Beijing. These chemicals together explained 38 and 24% on average of PM2.5-induced reactive oxygen species in Beijing and Guangzhou, respectively, while 60% of the effects remained to be resolved in terms of contributing chemicals. PAHs contributed approximately twice the share of the PM2.5 mixture effects as metals. Fe, Cu, and Mn were the dominant metals, constituting 80% of the metal-shared proportion of the PM2.5 effects. Dibenzo[a,l]pyrene alone explained 65% of the PAH-shared proportion of the PM2.5 toxicity effects. The significant contribution from coal combustion and vehicular emissions in Beijing suggested the major source disparities of toxicologically active PAHs between the two cities. Our study provided novel quantitative insights into the role of varying toxic component profiles in shaping the differential toxic potencies of city-specific PM2.5 pollution.
机译：越来越多的文献记录了特定来源或特定地点的细颗粒物（PM2.5）的不同毒性，这与考虑到对组分毒性的不完全理解而将颗粒毒性视作独立于成分的做法相反。从混合物的角度出发，量化特定组分的贡献是释放颗粒毒性的地理差异的关键。在这项研究中，我们进行了综合的混合物毒性实验和建模，以量化金属和多环芳烃（PA2.5）的两个默认的罪魁祸首组分组PM2.5对北京冬季PM2.5引起的体外氧化应激的贡献。广州和中国两个特大城市。来自北京的PM2.5在相同质量浓度下表现出更大的毒性。有针对性的化学分析显示，北京每单位质量PM2.5的金属和PAH含量更高。在北京和广州，这些化学物质分别平均解释了PM2.5诱导的活性氧种类的38％和24％，而在贡献化学物质方面，仍有60％以上的影响尚待解决。 PAH贡献的PM2.5混合物效应是金属的两倍。铁，铜和锰是主要金属，占PM2.5效应中金属份额的80％以上。单独的二苯并[a，l] py解释了PM2.5毒性作用中PAH共享比例的> 65％。在北京，煤炭燃烧和车辆排放产生的巨大影响表明，这两个城市之间毒理活性多环芳烃的主要来源差异。我们的研究提供了新颖的定量见解，探讨了各种有毒成分在塑造城市特定PM2.5污染的不同毒性潜力中的作用。

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  • 来源
    《Environmental Science & Technology》 |2019年第5期|2881-2891|共11页
  • 作者

    Jin Ling; Xie Jiawen; Wong Chris K. C.; Chan Serena K. Y.; Abbaszade Guelcin; Schnelle-Kreis Juergen; Zimmermann Ralf; Li Jun; Zhang Gan; Fu Pingqing; Li Xiangdong;

  • 作者单位

    Hong Kong Polytech Univ, Dept Civil & Environm Engn, Hung Horn, Kowloon, Hong Kong, Peoples R China|Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen 518057, Guangdong, Peoples R China;

    Hong Kong Polytech Univ, Dept Civil & Environm Engn, Hung Horn, Kowloon, Hong Kong, Peoples R China|Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen 518057, Guangdong, Peoples R China;

    Hong Kong Baptist Univ, Croucher Inst Environm Sci, Dept Biol, Kowloon Tong, Hong Kong, Peoples R China;

    Hong Kong Baptist Univ, Croucher Inst Environm Sci, Dept Biol, Kowloon Tong, Hong Kong, Peoples R China;

    Helmholtz Zentrum Munchen HMGU, Joint Mass Spectrometry Ctr, Comprehens Mol Analyt, D-85764 Neuherberg, Germany;

    Helmholtz Zentrum Munchen HMGU, Joint Mass Spectrometry Ctr, Comprehens Mol Analyt, D-85764 Neuherberg, Germany;

    Helmholtz Zentrum Munchen HMGU, Joint Mass Spectrometry Ctr, Comprehens Mol Analyt, D-85764 Neuherberg, Germany|Univ Rostock UR IC, Joint Mass Spectrometry Ctr, Chair Analyt Chem, D-18059 Rostock, Germany;

    Chinese Acad Sci, State Key Lab Organ Geochem, Guangzhou Inst Geochem, Guangzhou 510640, Guangdong, Peoples R China;

    Chinese Acad Sci, State Key Lab Organ Geochem, Guangzhou Inst Geochem, Guangzhou 510640, Guangdong, Peoples R China;

    Tianjin Univ, Inst Surface Earth Syst Sci, Tianjin 300072, Peoples R China;

    Hong Kong Polytech Univ, Dept Civil & Environm Engn, Hung Horn, Kowloon, Hong Kong, Peoples R China|Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen 518057, Guangdong, Peoples R China;

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