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Metabolomics of Children and Adolescents Exposed to Industrial Carcinogenic Pollutants

机译：暴露于工业致癌污染物的儿童和青少年的代谢组学

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摘要

Studies on metabolomes of carcinogenic pollutants among children and adolescents are limited. We aim to identify metabolic perturbations in 107 children and adolescents (aged 9-15) exposed to multiple carcinogens in a polluted area surrounding the largest petrochemical complex in Taiwan. We measured urinary concentrations of eight carcinogen exposure biomarkers (heavy metals and polycyclic aromatic hydrocarbons (PAHs) represented by 1-hydroxypyrene), and urinary oxidative stress biomarkers and serum acylcarnitines as biomarkers of early health effects. Serum metabolomics was analyzed using a liquid chromatography mass spectrometry-based method. Pathway analysis and "meet-in-the-middle" approach were applied to identify potential metabolites and biological mechanisms linking carcinogens exposure with early health effects. We found 10 potential metabolites possibly linking increased exposure to IARC group 1 carcinogens (As, Cd, Cr, Ni) and group 2 carcinogens (V, Hg, PAHs) with elevated oxidative stress and deregulated serum acylcarnitines, including inosine monophosphate and adenosine monophosphate (purine metabolism), malic acid and oxoglutaric acid (citrate cycle), carnitine (fatty acid metabolism), and pyroglutamic acid (glutathione metabolism). Purine metabolism was identified as the possible mechanism affected by children and adolescents' exposure to carcinogens. These findings contribute to understanding the health effects of childhood and adolescence exposure to multiple industrial carcinogens during critical periods of development.
机译：儿童和青少年中致癌污染物代谢组的研究是有限的。我们的目标是确定台湾最大的石化综合体周围污染地区的107位暴露于多种致癌物的儿童和青少年（9-15岁）的代谢紊乱。我们测量了八种致癌物暴露生物标志物（以1-羟基py为代表的重金属和多环芳烃（PAHs））的尿液浓度，以及尿液氧化应激生物标志物和血清酰基肉碱作为早期健康影响的生物标志物。使用基于液相色谱质谱法的方法分析血清代谢组学。应用途径分析和“中间相遇”方法来鉴定潜在的代谢物和将致癌物暴露与早期健康影响联系起来的生物学机制。我们发现10种潜在的代谢产物可能与IARC第1组致癌物（As，Cd，Cr，Ni）和第2组致癌物（V，Hg，PAHs）的暴露增加有关，具有较高的氧化应激水平和血清酰基肉碱含量失调，包括肌苷一磷酸和腺苷一磷酸（嘌呤代谢），苹果酸和氧戊二酸（柠檬酸盐循环），肉碱（脂肪酸代谢）和焦谷氨酸（谷胱甘肽代谢）。嘌呤的代谢被确定为可能受到儿童和青少年接触致癌物影响的机制。这些发现有助于了解儿童和青少年在发育的关键时期接触多种工业致癌物对健康的影响。

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  • 来源
    《Environmental Science & Technology》 |2019年第9期|5454-5465|共12页
  • 作者

    Chen Chi-Hsin S.; Kuo Tien-Chueh; Kuo Han-Chun; Tseng Yufeng J.; Kuo Ching-Hua; Yuan Tzu-Hsuen; Chan Chang-Chuan;

  • 作者单位

    Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, 17 Xu Zhou Rd, Taipei 10055, Taiwan;

    Natl Taiwan Univ, Ctr Genom Med, Metabol Core Lab, 1 Sec 4,Roosevelt Rd, Taipei 10617, Taiwan|Natl Taiwan Univ, Coll Elect Engn & Comp Sci, Grad Inst Biomed Elect & Bioinformat, 1 Sec 4,Roosevelt Rd, Taipei 10617, Taiwan;

    Natl Taiwan Univ, Ctr Genom Med, Metabol Core Lab, 1 Sec 4,Roosevelt Rd, Taipei 10617, Taiwan;

    Natl Taiwan Univ, Coll Elect Engn & Comp Sci, Grad Inst Biomed Elect & Bioinformat, 1 Sec 4,Roosevelt Rd, Taipei 10617, Taiwan|Natl Taiwan Univ, Coll Elect Engn & Comp Sci, Dept Comp Sci & Informat Engn, 1 Sec 4,Roosevelt Rd, Taipei 10617, Taiwan;

    Natl Taiwan Univ, Sch Pharm, Coll Med, 33 Linsen S Rd, Taipei 10055, Taiwan;

    Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, 17 Xu Zhou Rd, Taipei 10055, Taiwan;

    Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, 17 Xu Zhou Rd, Taipei 10055, Taiwan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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