...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Slow-Release Implants for Manipulating Contaminant Exposures in Aquatic Wildlife: A New Tool for Field Ecotoxicology
【24h】

Slow-Release Implants for Manipulating Contaminant Exposures in Aquatic Wildlife: A New Tool for Field Ecotoxicology

机译：缓释植入物以控制水生野生生物中的污染物暴露：田间生态毒理学的新工具

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Field-based ecotoxicology studies are invaluable for uncovering the effects of contaminants of emerging concern (CECs) on aquatic organisms. However, large-scale exposures are still very rare due to prohibitive costs, the availability of replicated habitats, and the potential for exposure to cause lasting damage to the environment. Here, we evaluated the viability of internal slow-release implants as an alternative method for manipulating CEC exposures in aquatic wildlife using two fat-based carriers (coconut oil and vegetable shortening). We treated roach (Rutilus rutilus) with implants containing a high (50 mu g/g), low (25 mu g/g), or control (0 mu g/g) concentration of the behavior-modifying pharmaceutical oxazepam. We then measured oxazepam uptake in four tissues (plasma, muscle, liver, and the brain) over 1 month. The two carriers released oxazepam differently: coconut oil was the superior implant type because it delivered a more consistent dose across time, while vegetable shortening released oxazepam rapidly at the start of the exposure period. For both carriers and treatments, the brain and liver contained the most oxazepam. Overall, the method is a promising technique for controlled manipulations of pharmaceuticals in fish, and we have provided some of the first data on the suitability and contaminant release kinetics from different implant types.
机译：基于现场的生态毒理学研究对于揭示新兴关注的污染物（CEC）对水生生物的影响是无价的。但是，由于成本过高，可复制的栖息地的可用性以及可能对环境造成持久破坏的潜在暴露，大规模暴露仍然很少。在这里，我们使用两种基于脂肪的载体（椰子油和蔬菜起酥油）评估了内部缓释植入物的可行性，以作为控制水生野生生物中CEC暴露的替代方法。我们用含有高（50微克/克），低（25微克/克）或对照（0微克/克）浓度的行为改良药物奥沙西m的植入物处理了蟑螂（Rutilus rut​​ilus）。然后，我们在1个月内测量了四个组织（血浆，肌肉，肝脏和大脑）中奥沙西m的摄入量。两种载体释放奥沙西m的方式不同：椰子油是优越的植入物类型，因为椰子油在整个时间范围内提供的剂量更加一致，而蔬菜起酥油则在暴露期开始时迅速释放了奥沙西m。对于载体和治疗，大脑和肝脏中的奥沙西m含量最高。总的来说，该方法是一种有前途的技术，可用于鱼类中药物的控制操作，我们提供了有关不同植入物类型的适应性和污染物释放动力学的一些初步数据。

著录项

  • 来源
    《Environmental Science & Technology》 |2019年第14期|8282-8290|共9页
  • 作者

    McCallum Erin S.; Cerveny Daniel; Fick Jerker; Brodin Tomas;

  • 作者单位

    Umea Univ, Dept Ecol & Environm Sci, SE-90187 Umea, Sweden|Swedish Univ Agr Sci SLU, Dept Wildlife Fish & Environm Studies, SE-90183 Umea, Sweden;

    Umea Univ, Dept Chem, SE-90187 Umea, Sweden|Univ South Bohemia Ceske Budejovice, Fac Fisheries & Protect Waters, South Bohemian Res Ctr Aquaculture & Biodivers Hy, Res Inst Fish Culture & Hydrobiol, Zatisi 728-2, Vodnany 38925, Czech Republic;

    Umea Univ, Dept Chem, SE-90187 Umea, Sweden;

    Swedish Univ Agr Sci SLU, Dept Wildlife Fish & Environm Studies, SE-90183 Umea, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号