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首页> 外文期刊>Environmental Science & Technology >Slow-Release Implants for Manipulating Contaminant Exposures in Aquatic Wildlife: A New Tool for Field Ecotoxicology
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Slow-Release Implants for Manipulating Contaminant Exposures in Aquatic Wildlife: A New Tool for Field Ecotoxicology

机译:用于操纵水生野生动物中的污染物暴露的缓慢植入物:一种新的生态毒理学工具

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摘要

Field-based ecotoxicology studies are invaluable for uncovering the effects of contaminants of emerging concern (CECs) on aquatic organisms. However, large-scale exposures are still very rare due to prohibitive costs, the availability of replicated habitats, and the potential for exposure to cause lasting damage to the environment. Here, we evaluated the viability of internal slow-release implants as an alternative method for manipulating CEC exposures in aquatic wildlife using two fat-based carriers (coconut oil and vegetable shortening). We treated roach (Rutilus rutilus) with implants containing a high (50 mu g/g), low (25 mu g/g), or control (0 mu g/g) concentration of the behavior-modifying pharmaceutical oxazepam. We then measured oxazepam uptake in four tissues (plasma, muscle, liver, and the brain) over 1 month. The two carriers released oxazepam differently: coconut oil was the superior implant type because it delivered a more consistent dose across time, while vegetable shortening released oxazepam rapidly at the start of the exposure period. For both carriers and treatments, the brain and liver contained the most oxazepam. Overall, the method is a promising technique for controlled manipulations of pharmaceuticals in fish, and we have provided some of the first data on the suitability and contaminant release kinetics from different implant types.
机译:基于田间的生态毒理学研究对于揭示新兴问题(CEC)对水生生物的污染物的影响非常宝贵。然而,由于成本令人满意的成本,复制栖息地的可用性以及暴露导致环境损害的可能性,大规模曝光仍然非常罕见。在这里,我们评估了内部缓释植入物的可行性作为使用两种脂肪的携带者(椰子油和蔬菜缩短)在水生野生动物中操纵CEC暴露的替代方法。我们用含有高(50μg),低(25μg/ g),或对照(0μg/ g)浓度的行为改性药物恶化的植入物治疗了蟑螂(rutilus rut​​ilus)。然后,我们在1个月内测定了4种组织(血浆,肌肉,肝脏和大脑)中的莫西阿西泮吸收。这两个载体释放出不同的牛油泮:椰子油是优越的植入物类型,因为它在越来越多的时间递送了更一致的剂量,而植物缩短在暴露期开始迅速释放恶化泮。对于载体和治疗,大脑和肝脏含有最多的牛皮泮。总体而言,该方法是用于对鱼类药物的控制操作的有希望的技术,我们提供了一些关于来自不同植入物类型的适用性和污染物释放动力学的一些数据。

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  • 来源
    《Environmental Science & Technology》 |2019年第14期|8282-8290|共9页
  • 作者单位

    Umea Univ Dept Ecol & Environm Sci SE-90187 Umea Sweden|Swedish Univ Agr Sci SLU Dept Wildlife Fish & Environm Studies SE-90183 Umea Sweden;

    Umea Univ Dept Chem SE-90187 Umea Sweden|Univ South Bohemia Ceske Budejovice Fac Fisheries & Protect Waters South Bohemian Res Ctr Aquaculture & Biodivers Hy Res Inst Fish Culture & Hydrobiol Zatisi 728-2 Vodnany 38925 Czech Republic;

    Umea Univ Dept Chem SE-90187 Umea Sweden;

    Swedish Univ Agr Sci SLU Dept Wildlife Fish & Environm Studies SE-90183 Umea Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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