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Size-Dependent Bacterial Toxicity of Hematite Particles

机译：赤铁矿颗粒的尺寸依赖性细菌毒性

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摘要

Submicron-sized iron oxide particles can influence the activity of bacteria, but the exact mechanisms of oxide toxicity toward bacteria remain elusive. By using atomic force microscopy (AFM), soft X-ray tomography (Nano-CT), and Fourier transform infrared (FTIR) spectrometry, we show how the size-dependent interfacial interactions between hematite particles and bacteria in the absence of any ligands contribute to the antimicrobial properties against Gram-positive and Gram-negative bacterial strains. We found that surface adhesion between hematite particles and bacterial cells is initially dominated by Lifshitz van der Waals and electrostatic forces. Subsequently, the rapid formation of P-O-Fe bonds occurs, followed by changes in the structures of membrane proteins in 2 h, resulting in the loss of the structural integrity of the membrane within 10 h. Thus, particles can migrate into the cells. After contact with bacterial cells, reactive oxygen species are generated on the surface of hematite particles, leading to cell permeabilization. G(-) bacteria appear to be more susceptible to this process than G(+) bacteria because the latter exhibit weaker adhesion forces toward hematite and benefit from the protective effects of the peptidoglycan layers. Our work revealed that hematite nanoparticles are more toxic to bacteria than microscaled particles due to their strong interfacial physicochemical interactions with the cells.
机译：亚微米大小的氧化铁颗粒可以影响细菌的活性，但是氧化物对细菌毒性的确切机制仍然难以捉摸。通过使用原子力显微镜（AFM），软X射线断层扫描（Nano-CT）和傅立叶变换红外（FTIR）光谱，我们显示了在没有任何配体的情况下赤铁矿颗粒与细菌之间的尺寸依赖性界面相互作用是如何产生的对革兰氏阳性和革兰氏阴性细菌菌株的抗菌性能。我们发现，赤铁矿颗粒和细菌细胞之间的表面附着力最初主要由Lifshitz van der Waals和静电力控制。随后，P-O-Fe键快速形成，然后在2小时内改变膜蛋白的结构，导致10小时内膜结构完整性的丧失。因此，颗粒可以迁移到细胞中。与细菌细胞接触后，赤铁矿颗粒表面会产生活性氧，导致细胞通透。 G（-）细菌似乎比G（+）细菌更容易受到此过程的影响，因为G（+）细菌对赤铁矿的粘附力较弱，并受益于肽聚糖层的保护作用。我们的工作表明，赤铁矿纳米颗粒由于其与细胞的强界面物理化学相互作用，因此对微生物的毒性要比微米级颗粒高。

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  • 来源
    《Environmental Science & Technology》 |2019年第14期|8147-8156|共10页
  • 作者

    Qu Chenchen; Qian Shufang; Chen Liang; Guan Yong; Zheng Lei; Liu Shuhu; Chen Wenli; Cai Peng; Huang Qiaoyun;

  • 作者单位

    Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China|Huazhong Agr Univ, Hubei Key Lab Soil Environm & Pollut Remediat, Wuhan 430070, Hubei, Peoples R China;

    Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China;

    Univ Sci & Technol China, Natl Synchrotron Radiat Lab, Hefei 230029, Anhui, Peoples R China;

    Univ Sci & Technol China, Natl Synchrotron Radiat Lab, Hefei 230029, Anhui, Peoples R China;

    Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing 100039, Peoples R China;

    Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing 100039, Peoples R China;

    Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China;

    Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China|Huazhong Agr Univ, Hubei Key Lab Soil Environm & Pollut Remediat, Wuhan 430070, Hubei, Peoples R China;

    Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China|Huazhong Agr Univ, Hubei Key Lab Soil Environm & Pollut Remediat, Wuhan 430070, Hubei, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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