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Size-Dependent Bacterial Toxicity of Hematite Particles

机译：赤铁矿颗粒的大小依赖性细菌毒性

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摘要

Submicron-sized iron oxide particles can influence the activity of bacteria, but the exact mechanisms of oxide toxicity toward bacteria remain elusive. By using atomic force microscopy (AFM), soft X-ray tomography (Nano-CT), and Fourier transform infrared (FTIR) spectrometry, we show how the size-dependent interfacial interactions between hematite particles and bacteria in the absence of any ligands contribute to the antimicrobial properties against Gram-positive and Gram-negative bacterial strains. We found that surface adhesion between hematite particles and bacterial cells is initially dominated by Lifshitz van der Waals and electrostatic forces. Subsequently, the rapid formation of P-O-Fe bonds occurs, followed by changes in the structures of membrane proteins in 2 h, resulting in the loss of the structural integrity of the membrane within 10 h. Thus, particles can migrate into the cells. After contact with bacterial cells, reactive oxygen species are generated on the surface of hematite particles, leading to cell permeabilization. G(-) bacteria appear to be more susceptible to this process than G(+) bacteria because the latter exhibit weaker adhesion forces toward hematite and benefit from the protective effects of the peptidoglycan layers. Our work revealed that hematite nanoparticles are more toxic to bacteria than microscaled particles due to their strong interfacial physicochemical interactions with the cells.
机译：亚微米尺寸的氧化铁颗粒可以影响细菌的活性，但氧化毒性对细菌的确切机制仍然难以捉摸。通过使用原子力显微镜（AFM），软X射线断层扫描（NANO-CT）和傅里叶变换红外（FTIR）光谱法，我们展示了在没有任何配体的情况下呈现赤铁矿颗粒和细菌之间的大小依赖性界面相互作用抗血管阳性和革兰氏阴性细菌菌株的抗微生物性质。我们发现赤铁矿颗粒和细菌细胞之间的表面粘附最初由Lifshitz范德华和静电力占主导地位。随后，发生P-O-Fe键的快速形成，然后在2小时内进行膜蛋白结构的变化，导致10小时内膜的结构完整性损失。因此，颗粒可以迁移到细胞中。在接触细菌细胞后，在赤铁矿颗粒表面上产生反应性氧物质，导致细胞透化。 G（ - ）细菌似乎比G（+）细菌更容易受到该过程的影响，因为后者表现出较弱的粘附力朝赤铁矿并受益于肽聚糖层的保护作用。我们的工作表明，由于与细胞的强界面物理化学相互作用强，赤铁矿纳米颗粒对细菌的毒性更大。

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  • 来源
    《Environmental Science & Technology》 |2019年第14期|8147-8156|共10页
  • 作者

    Qu Chenchen; Qian Shufang; Chen Liang; Guan Yong; Zheng Lei; Liu Shuhu; Chen Wenli; Cai Peng; Huang Qiaoyun;

  • 作者单位

    Huazhong Agr Univ State Key Lab Agr Microbiol Wuhan 430070 Hubei Peoples R China|Huazhong Agr Univ Hubei Key Lab Soil Environm & Pollut Remediat Wuhan 430070 Hubei Peoples R China;

    Huazhong Agr Univ State Key Lab Agr Microbiol Wuhan 430070 Hubei Peoples R China;

    Univ Sci & Technol China Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China;

    Univ Sci & Technol China Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China;

    Chinese Acad Sci Inst High Energy Phys Beijing Synchrotron Radiat Facil Beijing 100039 Peoples R China;

    Chinese Acad Sci Inst High Energy Phys Beijing Synchrotron Radiat Facil Beijing 100039 Peoples R China;

    Huazhong Agr Univ State Key Lab Agr Microbiol Wuhan 430070 Hubei Peoples R China;

    Huazhong Agr Univ State Key Lab Agr Microbiol Wuhan 430070 Hubei Peoples R China|Huazhong Agr Univ Hubei Key Lab Soil Environm & Pollut Remediat Wuhan 430070 Hubei Peoples R China;

    Huazhong Agr Univ State Key Lab Agr Microbiol Wuhan 430070 Hubei Peoples R China|Huazhong Agr Univ Hubei Key Lab Soil Environm & Pollut Remediat Wuhan 430070 Hubei Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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