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首页> 外文期刊>Environmental Science & Technology >Halogenated Organic Pollutant Residuals in Human Bared and Clothing-Covered Skin Areas: Source Differentiation and Comprehensive Health Risk Assessment
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Halogenated Organic Pollutant Residuals in Human Bared and Clothing-Covered Skin Areas: Source Differentiation and Comprehensive Health Risk Assessment

机译：人体裸露和衣服覆盖的皮肤区域中的卤化有机污染物残留：来源差异和全面的健康风险评估

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摘要

To comprehensively clarify human exposure to halogenated flame retardants (HFRs) and polychlorinated biphenyls (PCBs) through dermal uptake and hand-to-mouth intake, skin wipe samples from four typical skin locations from 30 volunteers were collected. The total concentration of the target chemicals (24 HFRs and 16 PCBs) ranged from 203 to 4470 ng/m(2). BDE-209 and DBDPE accounted for about 37 and 40% of Sigma(24)HFRs, respectively, and PCB-41 and PCB-110 were the dominant PCB congeners, with proportion of 24 and 10%, respectively. Although exhibiting relatively lower concentrations of contaminants than bared skin locations, clothing-covered skin areas were also detected with considerable levels of HFRs and PCBs, indicating clothing to be a potentially significant exposure source. Significant differences in HFR and PCB levels and profiles were also observed between males and females, with more lower-volatility chemicals in male-bared skin locations and more higher-volatility compounds in clothing-covered skin locations of female participants. The mean estimated whole-body dermal absorption doses of Sigma(8)HFRs and Sigma(16)PCBs (2.9 x 10(-4) and 6.7 x 10(-6) mg/kg.d) were 12 orders of magnitude higher than ingestion doses via hand-to-mouth contact (6.6 x 10(-7) and 3.1 x 10(-7) mg/kg.d). The total noncarcinogenic health risk resulted from whole-body dermal absorption and oral ingestion to Sigma(7)HFRs and Sigma(16)PCBs were 5.2 and 0.35, respectively.
机译：为了全面阐明人类通过皮肤吸收和手口摄入而暴露于卤化阻燃剂（HFR）和多氯联苯（PCB）的情况，收集了来自30名志愿者的四个典型皮肤部位的擦拭样本。目标化学品（24种HFR和16种PCB）的总浓度范围为203至4470 ng / m（2）。 BDE-209和DBDPE分别约占Sigma（24）HFR的37％和40％，PCB-41和PCB-110是主要的PCB同系物，分别占24％和10％。尽管与裸露的皮肤位置相比，污染物的浓度相对较低，但也检测到衣服覆盖的皮肤区域的HFR和PCB含量较高，表明衣服是潜在的重要暴露源。男性和女性之间也观察到HFR和PCB含量和分布的显着差异，在男性裸露的皮肤部位，挥发性较低的化学物质较多，在女性覆盖的皮肤位置，挥发性较高的化合物较多。估计的Sigma（8）HFRs和Sigma（16）PCBs的全身皮肤平均吸收剂量（2.9 x 10（-4）和6.7 x 10（-6）mg / kg.d）比其高12个数量级通过手口接触摄取的剂量（6.6 x 10（-7）和3.1 x 10（-7）mg / kg.d）。全身皮肤吸收和口服Sigma（7）HFRs和Sigma（16）PCBs引起的总非致癌健康风险分别为5.2和0.35。

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  • 来源
    《Environmental Science & Technology》 |2019年第24期|14700-14708|共9页
  • 作者

    Cao Zhiguo; Chen Qiaoying; Zhu Chunyou; Chen Xi; Wang Neng; Zou Wei; Zhang Xingli; Zhu Guifen; Li Jinghua; Mai Bixian; Luo Xiaojun;

  • 作者单位

    Henan Normal Univ Minist Educ Sch Environm Key Lab Yellow River & Huai River Water Environm Xinxiang 453007 Henan Peoples R China|Tsinghua Univ Beijing Key Lab Emerging Organ Contaminants Contr Beijing 100084 Peoples R China;

    Henan Normal Univ Minist Educ Sch Environm Key Lab Yellow River & Huai River Water Environm Xinxiang 453007 Henan Peoples R China;

    Chinese Acad Sci Guangzhou Inst Geochem State Key Lab Organ Geochem Guangzhou 510640 Guangdong Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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