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首页> 外文期刊>Environmental Science & Technology >Occurrence and Maternal Transfer of Multiple Bisphenols, Including an Emerging Derivative with Unexpectedly High Concentrations, in the Human Maternal-Fetal-Placental Unit
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Occurrence and Maternal Transfer of Multiple Bisphenols, Including an Emerging Derivative with Unexpectedly High Concentrations, in the Human Maternal-Fetal-Placental Unit

机译：在人类母胎-胎盘单元中多种双酚的发生和母体转移，包括具有高浓度的新兴衍生物

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In this study, a set of IS bisphenols (BPs) and one emerging derivative (4-hydroxyphenyl 4-isoprooxyphenylsulfone, BPS1P) were analyzed in 60 pairs of maternal plasma, cord plasma, and placenta samples from pregnant women in South China. A total of 4 of the 15 target BPs, i.e., BPA, bisphenol S (BPS), bisphenol AF (BPAF), and bisphenol E (BPE), were frequently detected in the three human biological matrixes. The derivative BPSIP was identified in all maternal plasma samples at unexpectedly high levels, second only to BPA. The concentrations of bisphenols in maternal plasma were slightly higher than in cord plasma for BPA, BPS, and BPE but much higher for BPSIP and much lower for BPAF, indicating that the five frequently detected bisphenols have different placental transfer behaviors. The placental transfer efficiencies (PTEs) of BPA, BPS, and BPE were similar, which were significantly higher than the PTE of BPSIP. The PTE of BPAF was much higher than other BPs, indicating its strong maternal transfer and high fetal accumulation. The PTEs of bisphenols were structure-dependent, and passive diffusion was suggested as the potential mechanism of placental transfer. Significant concentration correlations of the five major bisphenols between maternal plasma and cord plasma were observed (p < 0.05). Meanwhile, significant associations of BPAF concentrations in maternal/cord plasma with some maternal characteristics and adverse birth outcomes were also identified (p < 0.05).
机译：在这项研究中，对来自中国南方孕妇的60对产妇血浆，脐带血浆和胎盘样品中的一组IS双酚（BP）和一种新兴衍生物（4-羟苯基4-异丙氧基苯砜，BPS1P）进行了分析。在三个人类生物基质中，经常检测到15种目标BP中的总共4种，即BPA，双酚S（BPS），双酚AF（BPAF）和双酚E（BPE）。在所有孕妇血浆样品中鉴定出的衍生物BPSIP含量出乎意料地高，仅次于BPA。对于BPA，BPS和BPE，母体血浆中双酚的浓度略高于脐带血浆，但对于BPSIP，其双酚的浓度要高得多，而对于BPAF，则要低得多，这表明五种经常检测到的双酚具有不同的胎盘转移行为。 BPA，BPS和BPE的胎盘转移效率（PTE）相似，显着高于BPSIP的PTE。 BPAF的PTE远高于其他BP，表明其母体转移力强且胎儿积累高。双酚的PTE是结构依赖性的，并且被动扩散被认为是胎盘转移的潜在机制。观察到母体血浆和脐带血浆之间五种主要双酚的显着浓度相关性（p <0.05）。同时，还确定了母体/索德血浆中BPAF浓度与某些母体特征和不良分娩结果之间的显着相关性（p <0.05）。

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