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首页> 外文期刊>Environmental Science & Technology >Widespread Occurrence and Accumulation of Bisphenol A Diglycidyl Ether (BADGE), Bisphenol F Diglycidyl Ether (BFDGE) and Their Derivatives in Human Blood and Adipose Fat
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Widespread Occurrence and Accumulation of Bisphenol A Diglycidyl Ether (BADGE), Bisphenol F Diglycidyl Ether (BFDGE) and Their Derivatives in Human Blood and Adipose Fat

机译:双酚A二缩水甘油醚(BADGE),双酚F二缩水甘油醚(BFDGE)及其衍生物在人体血液和脂肪中的广泛发生和积累

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摘要

Despite the widespread use of bisphenol A diglycidyl ether (BADGE) and bisphenol F diglycidyl ether (BFDGE) in various consumer products, studies on human exposure to these compounds are scarce. In this study, BADGE, BFDGE, and seven of their derivatives were determined in human adipose fat and blood plasma samples collected from New York City, NY. Bisphenol A bis (2,3-dihydroxypropyl) ether [BADGE•2H_2O] was the major BADGE derivative found in 60% of the adipose samples and 7096 of the plasma samples analyzed. High concentrations and detection frequencies of BFDGE were found in both adipose and plasma samples. BFDGE concentrations in adipose fat ranged from 19.1 to 4500 ng/g wet weight A significant correlation between BADGE or BFDGE and their derivatives in adipose and plasma samples suggested hydration of these reactive compounds in humans. A significant positive correlation existed between BADGEs (i.e., the sum of BADGE and its five derivatives) and BFDGEs in adipose samples, which suggested similar exposure sources and pathways for these compounds in humans. Bisphenol A (BPA) also was analyzed in adipose fat and plasma, and its concentrations were positively correlated with those of BADGEs, which confirmed coexposure of BADGEs and BPA in humans.
机译:尽管双酚A二缩水甘油醚(BADGE)和双酚F二缩水甘油醚(BFDGE)在各种消费产品中得到了广泛使用,但是关于人体暴露于这些化合物的研究却很少。在这项研究中,BADGE,BFDGE及其七种衍生物是从纽约州纽约市收集的人体脂肪和血浆样品中测定的。双酚A双(2,3-二羟丙基)醚[BADGE•2H_2O]是在60%的脂肪样品和7096个血浆样品中发现的主要BADGE衍生物。在脂肪和血浆样品中均发现了高浓度和BFDGE检测频率。脂肪脂肪中BFDGE的浓度范围为19.1至4500 ng / g湿重。脂肪和血浆样品中BADGE或BFDGE及其衍生物之间的显着相关性表明这些反应性化合物在人体中会水合。脂肪样品中的BADGE(即BADGE及其五种衍生物的总和)与BFDGE之间存在显着的正相关,这表明这些化合物在人体内的暴露源和途径相似。还在脂肪和血浆中分析了双酚A(BPA),其浓度与BADGE的含量呈正相关,这证实了BADGE和BPA在人体中的共同暴露。

著录项

  • 来源
    《Environmental Science & Technology》 |2015年第5期|3150-3157|共8页
  • 作者单位

    Tianjin Key Laboratory of Environmental Remediation and Pollution Control/Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, Nankai University, Tianjin 300071, China,Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, P.O. Box 509, Albany, New York 12210-0509, United States;

    Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, P.O. Box 509, Albany, New York 12210-0509, United States;

    Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, P.O. Box 509, Albany, New York 12210-0509, United States,Biochemistry Department, Faculty of Science and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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