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首页> 外文期刊>Environmental Science & Technology >DNA Methylome Marks of Exposure to Particulate Matter at Three Time Points in Early Life
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DNA Methylome Marks of Exposure to Particulate Matter at Three Time Points in Early Life

机译：DNA甲基甲基汞在早期的三个时间点暴露于颗粒物质

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摘要

Maternal exposure to airborne particulate matter (PM) has been associated with restricted fetal growth and reduced birthweight. Here, we performed methylome-wide analyses of cord and children's blood DNA in relation to residential exposure to PM smaller than 10 mu m (PM10). This study included participants of the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC, cord blood, n = 780; blood at age 7, n = 757 and age 15-17, n = 850) and the EXPosOMICS birth cohort consortium including cord blood from ENVIRON-AGE (n = 197), INMA (n = 84), Piccolipiu (n = 99) and Rhea (n = 75). We could not identify significant CpG sites, by meta-analyzing associations between maternal PM10 exposure during pregnancy and DNA methlation in cord blood, nor by studying DNA methylation and concordant annual exposure at 7 and 15-17 years. The CpG cg21785536 was inversly associated with PM10 exposure using a longitudinal model integrating the three studied age groups (-1.2% per 10 mu g/m(3); raw p-value = 3.82 X 10(-8)). Pathway analyses on the corresponding genes of the 100 strongest associated CpG sites of the longitudinal model revealed enriched pathways relating to the GABAergic synapse, p53 signaling and NOTCH1. We provided evidence that residential PM10 exposure in early life affects methylation of the CpG cg21785536 located on the EGF Domain Specific O-Linked N-Acetylglucosamine Transferase gene.
机译：母体暴露于空中颗粒物质（PM）与胎儿生长和减少的胎儿生长有关。在这里，我们对脐带和儿童血液DNA进行的甲基族 - 覆盖物分析与小于10μm（PM10）的PM的住宿暴露。本研究包括艾薇儿童纵向研究的参与者对妊娠和儿童（Alspac，脐带血，N = 780;血液7岁，N = 757岁和15-17岁，N = 850）以及包括脐带血从环境（n = 197），inma（n = 84），piccolipiu（n = 99）和rhea（n = 75）。通过在妊娠期和DNA甲酸中的母体PM10暴露之间的母体PM10暴露之间的关联，我们无法识别重要的CPG网站，也不能在7和15-17岁处学习DNA甲基化和一定的年度暴露。 CPG CG21785536使用整合三次学龄基团的纵向模型与PM10曝光有关（-1.2％/每10μg/ m（3）;原始p值= 3.82 x 10（-8））。在纵向模型的100个最强相关CpG位点的相应基因上分析纵向模型的相应基因显示富集的富集伴侣突触，P53信号和Notch1有关。我们提供了证据，即早期生命中的住宅PM10暴露会影响位于EGF结构域特异性O型o乙酰葡糖胺转移酶基因上的CPG CG21785536的甲基化。

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  • 来源
    《Environmental Science & Technology》 |2018年第9期|5427-5437|共11页
  • 作者

    Plusquin Michelle; Chadeau-Hyam Marc; Ghantous Akram; Alfano Rossella; Bustamante Mariona; Chatzi Leda; Cuenin Cyrille; Gulliver John; Herceg Zdenko; Kogevinas Manolis; Nawrot Tim S.; Pizzi Costanza; Porta Daniela; Relton Caroline L.; Richiardi Lorenzo; Robinson Oliver; Sunyer Jordi; Vermeulen Roel; Vriens Annette; Vrijheid Martine; Henderson John; Vineis Paolo;

  • 作者单位

    Hasselt Univ Ctr Environm Sci Hasselt Belgium|Imperial Coll London Sch Publ Hlth Dept Epidemiol & Biostat London England|Imperial Coll London Med Res Council Hlth Protect Agcy Ctr Environm & London England;

    Imperial Coll London Sch Publ Hlth Dept Epidemiol & Biostat London England|Imperial Coll London Med Res Council Hlth Protect Agcy Ctr Environm & London England|Univ Utrecht Div Environm Epidemiol IRAS Utrecht Netherlands;

    IARC 150 Cours Albert Thomas F-69008 Lyon France;

    Hasselt Univ Ctr Environm Sci Hasselt Belgium|Imperial Coll London Sch Publ Hlth Dept Epidemiol & Biostat London England|Imperial Coll London Med Res Council Hlth Protect Agcy Ctr Environm & London England;

    Barcelona Inst Sci & Technol CRG Barcelona Spain|Consortium Biomed Res Epidemiol & Publ Hlth CIBER Madrid Spain|Ctr Res Environm Epidemiol CREAL ISGlobal Barcelona Spain|UPF Barcelona Catalonia Spain;

    Univ Southern Calif Dept Prevent Med Los Angeles CA 90007 USA|Univ Crete Dept Social Med Iraklion Crete Greece;

    IARC 150 Cours Albert Thomas F-69008 Lyon France;

    Imperial Coll London Med Res Council Hlth Protect Agcy Ctr Environm & London England;

    IARC 150 Cours Albert Thomas F-69008 Lyon France;

    Consortium Biomed Res Epidemiol & Publ Hlth CIBER Madrid Spain|Ctr Res Environm Epidemiol CREAL ISGlobal Barcelona Spain|UPF Barcelona Catalonia Spain|Hosp del Mar Med Res Inst IMIM Barcelona Spain;

    Hasselt Univ Ctr Environm Sci Hasselt Belgium|Leuven Univ Environm & Hlth Unit Leuven Belgium;

    Univ Turin Dept Med Sci Canc Epidemiol Unit CERMS Turin Italy|CPO Piemonte Turin Italy;

    Lazio Reg Hlth Serv Dept Epidemiol Rome Italy;

    Univ Bristol Bristol Med Sch Dept Populat Hlth Sci MRC Integrat Epidemiol Unit Bristol Avon England;

    Univ Turin Dept Med Sci Canc Epidemiol Unit CERMS Turin Italy|CPO Piemonte Turin Italy;

    Imperial Coll London Sch Publ Hlth Dept Epidemiol & Biostat London England|Imperial Coll London Med Res Council Hlth Protect Agcy Ctr Environm & London England;

    Consortium Biomed Res Epidemiol & Publ Hlth CIBER Madrid Spain|Ctr Res Environm Epidemiol CREAL ISGlobal Barcelona Spain|Hosp del Mar Med Res Inst IMIM Barcelona Spain;

    Imperial Coll London Med Res Council Hlth Protect Agcy Ctr Environm & London England|Univ Utrecht Div Environm Epidemiol IRAS Utrecht Netherlands;

    Hasselt Univ Ctr Environm Sci Hasselt Belgium;

    Consortium Biomed Res Epidemiol & Publ Hlth CIBER Madrid Spain|Ctr Res Environm Epidemiol CREAL ISGlobal Barcelona Spain|UPF Barcelona Catalonia Spain;

    Univ Bristol Bristol Med Sch Dept Populat Hlth Sci Bristol Avon England;

    Hasselt Univ Ctr Environm Sci Hasselt Belgium|Imperial Coll London Sch Publ Hlth Dept Epidemiol & Biostat London England|Italian Inst Genom Med IIGM Turin Italy;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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