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首页> 外文期刊>Environmental Science & Technology >Microplastics Aggravate the Bioaccumulation of Two Waterborne Veterinary Antibiotics in an Edible Bivalve Species: Potential Mechanisms and Implications for Human Health
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Microplastics Aggravate the Bioaccumulation of Two Waterborne Veterinary Antibiotics in an Edible Bivalve Species: Potential Mechanisms and Implications for Human Health

机译：微塑料剂在食用双级物种中加剧了两种水性兽医抗生素的生物累积：潜在的机制和人类健康的影响

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摘要

Edible bivalves are one of the major types of seafood and may be subject to antibiotic and microplastics (MPs) coexposure under realistic scenarios. However, the effect of MPs on the bioaccumulation of antibiotics in edible bivalves and subsequent health risks for consumers remain poorly understood. Therefore, the bioaccumulation of two frequently detected veterinary antibiotics, oxytetracycline (OTC) and florfenicol (FLO), with or without the copresence of MPs was investigated in the blood clam. Health risks associated with the consumption of contaminated clams were also assessed. Furthermore, the activity of GST and expression of key detoxification genes were analyzed as well. The bioaccumulation of OTC and FLO in clams was found to be aggravated by MPs. Because the estimated target hazard quotients (THQs) were far less than the critical value, direct toxic effects of consuming contaminated clams are negligible. However, the dietary exposure doses of the human gut microbiota (DEGM) to the antibiotics tested were greater than or similar to corresponding minimum selective concentrations (MSC), indicating a potential antibiotic resistance risk. Moreover, the GST activity and expression of detoxification genes were significantly suppressed by MPs, suggesting that the disruption of detoxification represents one possible explanation for the aggravated bioaccumulation observed here.
机译：可食用的双抗性是海鲜的主要类型之一，可能受到抗生素和微塑料（MPS）群落的逼真。然而，MPS对食用双抗体和随后的消费者健康风险的抗生素生物累积的影响仍然清楚。因此，在血液蛤中研究了两种经常检测到的兽医抗生素，氧化胞菌素（OTC）和氟苯丙烯酸（Flo）的生物累积，氧化胞菌素（OTC）和氟苯丙烯酸（Flo）。还评估了与污染污染蛤蜊消耗相关的健康风险。此外，还分析了GST的活性和关键解毒基因的表达。发现OTC和FLO在蛤蜊中的生物累积被发现由MPS加剧。因为估计的目标危险版本（THQs）远小于临界值，所以消耗污染的蛤蜊的直接毒性效应可以忽略不计。然而，对测试的抗生素的人体肠道微生物（DEGM）的膳食曝光剂量大于或类似于相应的最小选择性浓度（MSC），表明潜在的抗生素抗性风险。此外，MPS显着抑制了GST活性和解毒基因的表达，表明解毒的破坏代表了这里观察到的加重生物累积的一个可能的解释。

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  • 来源
    《Environmental Science & Technology》 |2020年第13期|8115-8122|共8页
  • 作者

    Weishang Zhou; Yu Han; Yu Tang; Wei Shi; Xueying Du; Shuge Sun; Guangxu Liu;

  • 作者单位

    College of Animal Sciences Zhejiang University Hangzhou P.R. China;

    College of Animal Sciences Zhejiang University Hangzhou P.R. China;

    College of Animal Sciences Zhejiang University Hangzhou P.R. China;

    College of Animal Sciences Zhejiang University Hangzhou P.R. China;

    College of Animal Sciences Zhejiang University Hangzhou P.R. China;

    College of Animal Sciences Zhejiang University Hangzhou P.R. China;

    College of Animal Sciences Zhejiang University Hangzhou P.R. China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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