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首页> 外文期刊>Environmental Science & Technology >Differences in Neonicotinoid and Metabolite Sorption to Activated Carbon Are Driven by Alterations to the Insecticidal Pharmacophore
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Differences in Neonicotinoid and Metabolite Sorption to Activated Carbon Are Driven by Alterations to the Insecticidal Pharmacophore

机译：杀虫药物的改变驱动Neonicotinoid和代谢物吸附对活性炭的差异

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摘要

Widespread application of neonicotinoids has led to their proliferation in waters. Despite low neonicotinoid hydro-phobicity, our prior studies implicated granular activated carbon (GAC) in neonicotinoid removal. Based on known receptor binding characteristics, we hypothesized that the insecticidal pharmacophore influences neonicotinoid sorption. Our objectives were to illuminate drivers of neonicotinoid sorption for parent neonicotinoids (imidacloprid, clothianidin, thiamethoxam, and thiacloprid) and pharmacophore-altered metabolites (desnitro-imidacloprid and imidacloprid urea) to GAC, powdered activated carbon, and carbon nanotubes (CNTs). Neonicotinoid sorption to GAC was extensive and largely irreversible, with significantly greater sorption of imidacloprid than desnitro-imidacloprid. Imidacloprid and imidacloprid urea (electronegative pharmacophores) sorbed most extensively to nonfunctionalized CNTs, whereas desnitro-imidacloprid (positive pharmacophore) sorbed most to COOH-CNTs, indicating the importance of charge interactions and/or hydrogen bonding between the pharmacophore and carbon surface. Water chemistry parameters (temperature, alkalinity, ionic strength, and humic acid) inhibited overall neonicotinoid sorption, suggesting that pharmacophore-driven sorption in real waters may be diminished. Analysis of a full-scale drinking water treatment plant GAC filter influent, effluent, and spent GAC attributes neonicotinoid/metabolite removal to GAC under real-world conditions for the first time. Our Tesults demonstrate that the neonicotinoid pharmacophore not only confers insecticide selectivity but also impacts sorption behavior, leading to less effective removal of metabolites by GAC filters in water treatment.
机译：Neonicotinoids的广泛应用导致了它们在水中的增殖。尽管Neonicotinoid水疗法低，但我们的先前研究将含有颗粒状活性炭（GAC）在Neonicotinoid中除去。基于已知的受体结合特征，我们假设杀虫药物的影响是影响新烟碱蛋白吸附。我们的目标是照亮母细胞烟体（吡虫啉，乳蛋白，噻虫嗪和噻虫草）和药物改变的代谢物（Desnitro-Imidacloprid和咪酰胺啉）的司机对GAC，粉末活性炭和碳纳米管（CNT）的促进剂的驱动器。 Neonicotinoid对GAC的吸附是广泛的，很大程度上是不可逆转的，而胰岛酰上的吸附显着大于Desnitro-iniodacloprid。吡虫啉和吡虫啉尿素（电负基药物）含有最广泛的非功能化CNT，而Desnitro-ImidaCophoroprid（阳性药物）均吸附到COOH-CNT中，表明药物和碳表面之间的电荷相互作用和/或氢键合的重要性。水化学参数（温度，碱度，离子强度和腐殖酸）抑制了整体新烟碱蛋白吸附，表明真实水中的药物电解吸附可能会降低。分析全规模饮用水处理厂GAC滤光片流入，流出物，并将GAC属于Neonicotinoid /代谢物在Real-World条件下将Neonicotinoid /代谢物除去GAC第一次。我们的观察结果表明，Neonicotinoid PharmoChore不仅赋予杀虫剂选择性，而且影响吸附行为，导致GAC过滤器在水处理中缺乏效果去除代谢物。

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  • 来源
    《Environmental Science & Technology》 |2020年第22期|14694-14705|共12页
  • 作者

    Danielle T. Webb; Matthew R. Nagorzanski; Megan M. Powers; David M. Cwiertny; Michelle L. Hladik; Gregory H. LeFevre;

  • 作者单位

    Department of Civil &. Environmental Engineering University of Iowa Iowa City Iowa 52242 United States IIHR-Hydroscience & Engineering 100 C. Maxwell Stanley Hydraulics Laboratory Iowa City Iowa 52242 United States;

    Department of Civil & Environmental Engineering University of Iowa Iowa City Iowa 52242 United States IIHR-Hydroscience & Engineering 100 C. Maxwell Stanley Hydraulics Laboratory Iowa City Iowa 52242 United States;

    Department of Civil & Environmental Engineering University of Iowa Iowa City Iowa 52242 United States IIHR-Hydroscience & Engineering 100 C. Maxwell Stanley Hydraulics Laboratory Iowa City Iowa 52242 United States;

    Department of Civil & Environmental Engineering Center for Health Effects of Environmental Contamination and Public Policy Center University of Iowa Iowa City Iowa 52242 United States IIHR-Hydroscience & Engineering 100 C. Maxwell Stanley Hydraulics Laboratory Iowa City Iowa 52242 United States;

    U.S. Geological Survey California Water Science Center Sacramento California 95819 United States;

    Department of Civil & Environmental Engineering University of Iowa Iowa City Iowa 52242 United States IIHR-Hydroscience & Engineering 100 C. Maxwell Stanley Hydraulics Laboratory Iowa City Iowa 52242 United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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