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Evaluation of an Air Quality Health Index for Predicting the Mutagenicity of Simulated Atmospheres

机译：空气质量健康指数评估，以预测模拟大气的致突变性

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摘要

No study has evaluated the mutagenicity of atmospheres with a calculated air quality health index (AQHI). Thus, we generated in a UV-light-containing reaction chamber two simulated atmospheres (SAs) with similar AQHIs but different proportions of criteria pollutants and evaluated them for mutagenicity in three Salmonella strains at the air-agar interface. We continuously injected into the chamber gasoline, nitric oxide, and ammonium sulfate, as well as either α-pinene to produce SA-PM, which had a high concentration of particulate matter (PM): 119 ppb ozone (O_(3)), 321 ppb NO_(2), and 1007 μg/m~(3) PM_(2.5); or isoprene to produce SA-O_(3), which had a high ozone (O_(3)) concentration: 415 ppb O_(3), 633 ppb NO_(2), and 55 μg/m~(3) PM_(2.5). Neither PM_(2.5) extracts, NO_(2), or O_(3) alone, nor nonphoto-oxidized mixtures were mutagenic or cytotoxic. Both photo-oxidized atmospheres were largely direct-acting base-substitution mutagens with similar mutagenic potencies in TA100 and TA104. The mutagenic potencies [(revertants/h)/(mgC/m~(3))] of SA-PM (4.3 ± 0.4) and SA-O_(3) (9.5 ± 1.3) in TA100 were significantly different ( P P = 0.16), being ∼54% C → T and ∼46% C → A. Thus, the AQHI may have some predictive value for the mutagenicity of the gas phase of air.
机译：尚无研究用计算出的空气质量健康指数（AQHI）评估大气的致突变性。因此，我们在一个含有紫外线的反应室中产生了两个模拟的大气（SA），它们具有相似的AQHI，但是不同比例的标准污染物，并评估了它们在空气琼脂界面上对三种沙门氏菌菌株的致突变性。我们不断向室内注入汽油，一氧化氮和硫酸铵，以及任何一种α-pine烯，以生产出SA-PM，其中SA-PM的颗粒物浓度（PM）高：119 ppb臭氧（O_（3））， 321 ppb NO_（2）和1007μg/ m〜（3）PM_（2.5）;或异戊二烯制得具有较高臭氧（O_（3））浓度的SA-O_（3）：415 ppb O_（3），633 ppb NO_（2）和55μg/ m〜（3）PM_（2.5 ）。无论是PM_（2.5）提取物，NO_（2）还是O_（3）提取物，还是非光氧化混合物都不具有致突变性或细胞毒性。两种光氧化气氛都是直接作用的碱基取代诱变剂，在TA100和TA104中具有相似的诱变能力。 TA100中SA-PM（4.3±0.4）和SA-O_（3）（9.5±1.3）的致突变力[（回复量/ h）/（mgC / m〜（3））]显着不同（PP = 0.16 ），约为54％C→T和〜46％C→A。因此，AQHI对于空气气相的致突变性可能具有一定的预测价值。

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  • 来源
    《Environmental Science & Technology》 |2018年第5期|3045-3053|共9页
  • 作者

    Jose Zavala; Jonathan D. Krug; Sarah H. Warren; Q. Todd Krantz; Charly King; John McKee; Stephen H. Gavett; Michael Lewandowski; William A. Lonneman; Tadeusz E. Kleindienst; Matthew J. Meier; Mark Higuchi; M. Ian Gilmour; David M. DeMarini;

  • 作者单位

    ORISE Research Fellow, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    National Environmental Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    National Environmental Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    National Environmental Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    National Environmental Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    Biology Department, Carleton University, Ottawa, Ontario K1S 5B6, Canada;

    National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

    National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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