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首页> 外文期刊>Environmental Science & Technology >Interactions of ~(15)N-Sulfadiazine and Soil Components As Evidenced by ~(15)N-CPMAS NMR
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Interactions of ~(15)N-Sulfadiazine and Soil Components As Evidenced by ~(15)N-CPMAS NMR

机译：〜（15）N-CPMAS NMR证明〜（15）N-磺胺嘧啶与土壤组分的相互作用

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摘要

The extensive use of sulfonamides (SNs) in animal husbandry has led to an unintentional widespread occurrence in several environmental compartments. The implementation of regulations and management recommendations to reduce the potential risk of development of antibiotic resistances necessitates detailed knowledge on their fate in soil. We present results from two independent incubation studies of ~(15)N-labeled sulfadiazines (SDZ) which focused on identifying binding types in bound residues. In the first study ~(15)N-amino labeled SDZ was incubated with two previously isolated humic acids in the presence and absence of Trametes versicolor laccase, while in the second study ~(15)N-double-labeled SDZ was incubated with a typical agricultural Luvisol and the humic acid fraction isolated after sequential extraction of the soil. The freeze-dried humic acid fractions of both studies were then analyzed by ~(15)N-CPMAS NMR and compared with the ~(15)N-spectra of synthesized model compounds. In both studies amide bonds and Michael adducts were identified, while formation of imine bonds could be excluded. In the humic acid study, where less harsh extraction methods were applied, possible formation of H-bridging and sequestration were additionally detected.
机译：磺胺类药物（SNs）在畜牧业中的广泛使用已导致无意中在几个环境区室中普遍发生。为降低抗生素耐药性发展的潜在风险，法规和管理建议的实施需要对它们在土壤中的命运进行详细了解。我们提出了〜（15）N标记的磺胺嘧啶（SDZ）的两个独立的孵育研究的结果，这些研究重点在于确定结合残基中的结合类型。在第一个研究中，在存在和不存在Trametes versicolor漆酶的情况下，将（15）N-氨基标记的SDZ与两个以前分离的腐殖酸一起孵育，而在第二个研究中，将（15）N-双标记的SDZ与一个或两个条件下孵育。典型的农业Luvisol和在顺序提取土壤后分离出的腐殖酸级分。然后通过〜（15）N-CPMAS NMR分析两项研究的冻干腐殖酸级分，并与合成模型化合物的〜（15）N光谱进行比较。在两项研究中，均确定了酰胺键和迈克尔加合物，而亚胺键的形成可被排除。在腐殖酸研究中，采用了较少苛刻的提取方法，另外还检测到可能形成氢桥键和螯合。

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  • 来源
    《Environmental Science & Technology》 |2018年第6期|3748-3757|共10页
  • 作者

    Anne E. Berns; Herbert Philipp; Hans Lewandowski; Jeong-Heui Choi; Marc Lamshöft; Hans-Dieter Narres;

  • 作者单位

    Institute of Bio- and Geosciences (IBG-3) - Agrosphere, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany;

    Institute of Bio- and Geosciences (IBG-3) - Agrosphere, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany;

    Institute of Bio- and Geosciences (IBG-3) - Agrosphere, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany;

    Institute of Environmental Research (INFU), Dortmund University of Technology, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany;

    Institute of Environmental Research (INFU), Dortmund University of Technology, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany;

    Institute of Bio- and Geosciences (IBG-3) - Agrosphere, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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