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首页> 外文期刊>Environmental Science & Technology >Toxicokinetics of Crude Oil Components in Arctic Copepods
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Toxicokinetics of Crude Oil Components in Arctic Copepods

机译：北极Co足类中原油成分的毒代动力学

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摘要

The risk of accidental oil spills in the Arctic is on the rise due to increased shipping and oil exploration activities, making it essential to calibrate parameters for risk assessment of oil spills to Arctic conditions. The toxicokinetics of crude oil components were assessed by exposing one lipid-poor (CIII) and one lipid-rich (CV) stage of the Arctic copepod Calanus hyperboreus to crude oil WSF (water-soluble fraction). Water concentrations and total body residues (BR), as well as lipid volume fractions, were measured at regular intervals during exposure and recovery. Bioconcentration factors (BCFs) and elimination rates (k(e)) for 26 petrogenic oil components were estimated from one-compartment models fitted to the BR data. Our parameters were compared to estimations made by the OMEGA bioaccumulation model, which uses the octanol water partitioning coefficient (K-ow) in QSAR (quantitative structure activity relationship) predictions. Our parameters for the lipid-poor CIIIs generally agreed with the OMEGA predictions, while neither the BCFs nor the k(e)s for the lipid-rich CVs fitted within the realistic range of the OMEGA parameters. Both the uptake and elimination rates for the CVs were in general half an order of magnitude lower than the OMEGA predictions, showing an overestimation of these parameters by the OMEGA model.
机译：由于运输和石油勘探活动的增加，北极意外溢油的风险正在上升，因此必须校准参数以评估北极地区溢油的风险。通过将北极co足类Calanus hyperboreus的一个低脂阶段（CIII）和一个高脂阶段（CV）暴露于原油WSF（水溶性馏分）来评估原油成分的毒性动力学。在暴露和恢复过程中，定期测量水的浓度和体内总残留量（BR）以及脂质体积分数。根据适合BR数据的一室模型，估算了26种成岩油成分的生物富集系数（BCFs）和消除率（k（e））。我们的参数与OMEGA生物蓄积模型所作的估计进行了比较，该模型在QSAR（定量结构活性关系）预测中使用了辛醇水分配系数（K-ow）。我们的低脂CIII的参数通常与OMEGA的预测相符，而富含脂类CV的BCF和k（e）都不符合OMEGA参数的实际范围。 CV的吸收率和消除率通常都比OMEGA预测低半个数量级，这表明OMEGA模型对这些参数的估计过高。

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