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首页> 外文期刊>Environmental Science & Technology >Bioaccumulation and Biodistribution of Selenium in Metamorphosing Tadpoles
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Bioaccumulation and Biodistribution of Selenium in Metamorphosing Tadpoles

机译：变形Ta中硒的生物蓄积和生物分布

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摘要

Selenium is an important macronutrient with a very narrow margin between essentiality and toxicity. Amphibians are hypothesized to be particularly sensitive due to the potential for metamorphosis-driven mobilization, which could transfer or concentrate contaminant burdens within specific organs. We explored the potential role of tissue degeneration and remodeling during anuran metamorphosis as a mechanism for altering tissue-specific Se burdens. Limnodynastes peronii tadpoles were exposed to dissolved ~(75)Se (as selenite) for 7 days and depurated until completion of metamorphosis. Bioaccumulation and retention kinetics were assessed in whole tadpoles and excised tissues using gamma spectroscopy, and temporal changes in biodistribution were assessed using autoradiography. Tadpoles retained Se throughout metamorphosis, and partitioned the element predominantly within digestive and excretory tissues, including livers > mesonephros > guts > gallbladder. Importantly, our results demonstrate that Se biodistribution varies significantly throughout development. This is indicative of tissue transference, and particularly in tissues developing de novo after depuration. To the best of our knowledge, this is the first study demonstrating Se transference during metamorphic tissue remodelling. Further research is warranted to explore the fate and metabolism of Se (and other metal and metalloids) during anuran development and the implications of transference for influencing toxicity.
机译：硒是一种重要的常量营养素，其必需性和毒性之间的限度非常窄。据推测，两栖动物特别敏感，因为它具有由变态驱动的动员能力，它可以转移或集中特定器官内的污染物负担。我们探讨了无性变态过程中组织变性和重塑作为改变组织特异性硒负担的机制的潜在作用。将Permnii（Limnodynastes peronii）to暴露于溶解的〜（75）Se（作为亚硒酸盐）中7天，然后净化直至变态完成。使用伽马光谱法评估整个t和切除组织的生物蓄积和保留动力学，并使用放射自显影技术评估生物分布的时间变化。 throughout在整个变态过程中都保留了硒，并主要在消化和排泄组织（包括肝脏>中肾>肠>胆囊）中分配元素。重要的是，我们的结果表明，硒的生物分布在整个发育过程中都存在显着差异。这表明组织转移，特别是在净化后从头发展的组织中。据我们所知，这是第一个证明变质组织重塑过程中硒转移的研究。有必要进行进一步的研究，以探讨无水铀发育过程中硒（以及其他金属和准金属）的命运和代谢，以及转移对影响毒性的影响。

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  • 来源
    《Environmental Science & Technology》 |2017年第10期|5764-5773|共10页
  • 作者

    Chantal M. Lanctôt; Tom Cresswell; Paul D. Callaghan; Steven D. Melvin;

  • 作者单位

    Australi an Rivers Institute, School of Environment, Griffith University, Southport, Queensland 4215, Australia;

    Australian Nuclear Science and Technology Organisation (ANSTO), Locked Bag 2001, Kirrawee DC, New South Wales 2232, Australia;

    Australian Nuclear Science and Technology Organisation (ANSTO), Locked Bag 2001, Kirrawee DC, New South Wales 2232, Australia;

    Australi an Rivers Institute, School of Environment, Griffith University, Southport, Queensland 4215, Australia;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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