...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Analysis and Characterization of Polychlorinated Hydroxybornanes as Metabolites of Toxaphene Using a Polar Bear Model
【24h】

Analysis and Characterization of Polychlorinated Hydroxybornanes as Metabolites of Toxaphene Using a Polar Bear Model

机译：用北极熊模型分析和表征多氯代羟基冰片烷作为毒杀芬的代谢产物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abiotic and biotic transformation of toxaphene (camphechlor) results in the selective enrichment of recalcitrant congeners while other, less persistent compounds of technical toxaphene (CTTs) are degraded. Until now, there has been little knowledge on oxidation transformation of toxaphene. For instance, the existence of hydroxylated CTTs (OH-CTTs) in authentic environmental and food samples has not been proven. For this reason, we synthesized a mixture consisting of tetra- to heptachlorinated OH-CTTs and simplified it by countercurrent chromatography (CCC). Thus, 227 OH-CTTs were detected in the CCC fractions (12 tetra-, 117 penta-, 81 hexa-, and 17 heptachlorinated OH-CTTs), which was >50% more than detected before the fractionation. One CCC fraction consisting of only 18 OH-CTTs was used to develop a sample cleanup method which aimed to remove CTTs, isobaric PCBs, and sample matrix. The final cleanup procedure consisted of (i) gel permeation chromatography (GPC) and adsorption chromatography using (ii) deactivated and (iii) activated silica gel. Hence, up to 320 and 43S0 ^g/kg lipid weight of octa- and nonachlorinated CTTs were detected in four liver samples and adipose tissue of polar bears, respectively. Furthermore, the presence of one hexachlorinated OH-CTT isomer could be verified in the samples, which was about 1% of the octachlorinated CTTs determined in the liver samples.
机译：毒杀芬​​（甲草胺）的非生物和生物转化导致选择性顽固同源物的富集，而其他持久性较弱的工业毒杀芬（CTT）化合物则被降解。到目前为止，关于毒杀芬的氧化转化的知识还很少。例如，尚未证明真实环境和食品样品中存在羟基化CTT（OH-CTT）。因此，我们合成了由四氯化至七氯化的OH-CTT组成的混合物，并通过逆流色谱法（CCC）对其进行了简化。因此，在CCC馏分中检测到227个OH-CTT（12个四氯，117个五氟，81个六氯和17个七氯OH-CTT），比分馏前检测到的多50％。一种仅由18个OH-CTT组成的CCC馏分用于开发样品净化方法，旨在去除CTT，等压PCB和样品基质。最终的清洁程序包括（i）凝胶渗透色谱（GPC）和使用（ii）失活和（iii）活化硅胶的吸附色谱。因此，在北极熊的四个肝脏样本和脂肪组织中分别检测到高达320和43S0 ^ g / kg脂质重量的八氯和非氯化CTT。此外，可以在样品中验证一种六氯化OH-CTT异构体的存在，约占肝脏样品中八氯化CTTs的1％。

著录项

  • 来源
    《Environmental Science & Technology》 |2017年第15期|8335-8342|共8页
  • 作者

    Lea Reger; Christoph Gallistl; Karl Skimisson; Walter Vetter;

  • 作者单位

    Institute of Food Chemistry, University of Hohenheim, GarbenstraCe 28, D-70599 Stuttgart, Germany;

    Institute of Food Chemistry, University of Hohenheim, GarbenstraCe 28, D-70599 Stuttgart, Germany;

    University of Iceland, Keldur, Institute for Experimental Pathology, IS-112 Reykjavik, Iceland;

    Institute of Food Chemistry, University of Hohenheim, GarbenstraCe 28, D-70599 Stuttgart, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号