...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Incorporating Transgenerational Epigenetic Inheritance into Ecological Risk Assessment Frameworks
【24h】

Incorporating Transgenerational Epigenetic Inheritance into Ecological Risk Assessment Frameworks

机译：将跨代表观遗传纳入生态风险评估框架

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chronic exposure to environmental contaminants can induce heritable "transgenerational" modifications to organisms, potentially affecting future ecosystem health and functionality. Incorporating transgenerational epigenetic herit-ability into risk assessment procedures has been previously suggested. However, a critical review of existing literature yielded numerous studies claiming transgenerational impacts, with little compelling evidence. Therefore, contaminant-induced epigenetic inheritance may be less common than is reported in the literature. We identified a need for multi-generation epigenetic studies that extend beyond what could be deemed "direct exposure" to F1 and F2 gametes and also include subsequent multiple nonexposed generations to adequately evaluate transgenerational recovery times. Also, increased experimental replication is required to account for the highly variable nature of epigenetic responses and apparent ^reproducibility of current studies. Further, epigenetic end points need to be correlated with observable detrimental organism changes before a need for risk management can be properly determined. We suggest that epigenetic-based contaminant studies include concentrations lower than current "EC_(10-20)'' or "Lowest Observable Effect Concentrations" for the organism's most sensitive phenotypic end point, as higher concentrations are likely already regulated. Finally, we propose a regulatory framework and optimal experimental design that enables transgenerational epigenetic effects to be assessed and incorporated into conventional ecotoxtcological testing.
机译：长期暴露于环境污染物中会导致生物发生可遗传的“跨代”修饰，从而可能影响未来的生态系统健康和功能。以前曾建议将跨代表观遗传力纳入风险评估程序。但是，对现有文献的严格审查产生了许多声称具有跨代影响的研究，而没有令人信服的证据。因此，污染物诱导的表观遗传可能不如文献报道的普遍。我们确定了对多代表观遗传学研究的需求，这些研究应超出对F1和F2配子的“直接暴露”范围，并且还包括随后的多个未暴露世代，以充分评估跨代恢复时间。而且，需要增加实验复制来解释表观遗传反应的高度可变的性质和当前研究的表观可再现性。此外，在适当确定风险管理需求之前，需要将表观遗传学终点与可观察到的有害生物变化相关联。我们建议基于表观遗传学的污染物研究应包括低于该生物最敏感表型终点的当前“ EC_（10-20）”或“最低可观察作用浓度”的浓度，因为可能已经调节了较高的浓度。能够评估跨代表观遗传效应并将其纳入常规生态毒理学测试的监管框架和最佳实验设计。

著录项

  • 来源
    《Environmental Science & Technology》 |2017年第17期|9433-9445|共13页
  • 作者

    Jennifer LA Shaw; Jonathan D.Judy; Anupama Kumar; Paul Bertsch; Ming-Bo Wang; Jason K. Kirby;

  • 作者单位

    Commonwealth Scientific and Industrial Research Organisation (CSIRO), Land and Water, Environmental Contaminant Mitigation and Technologies Research Program, Waite Road, Urrbrae, Adelaide Australia, 5064;

    Commonwealth Scientific and Industrial Research Organisation (CSIRO), Land and Water, Environmental Contaminant Mitigation and Technologies Research Program, Waite Road, Urrbrae, Adelaide Australia, 5064,University of Florida, Soil and Water Sciences Department, 1692 McCarthy Drive, Gainesville, Florida 32611, United States;

    Commonwealth Scientific and Industrial Research Organisation (CSIRO), Land and Water, Environmental Contaminant Mitigation and Technologies Research Program, Waite Road, Urrbrae, Adelaide Australia, 5064;

    Commonwealth Scientific and Industrial Research Organisation (CSIRO), Land and Water, Brisbane, Queensland Australia, 4001;

    Commonwealth Scientific and Industrial Research Organisation (CSIRO), Agriculture and Food Unit, Black Mountain, Canberra, Australian Capital Territory, Australia, 2601;

    Commonwealth Scientific and Industrial Research Organisation (CSIRO), Land and Water, Environmental Contaminant Mitigation and Technologies Research Program, Waite Road, Urrbrae, Adelaide Australia, 5064;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号