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首页> 外文期刊>Environmental Science & Technology >Oil Exposure Impairs In Situ Cardiac Function in Response to β-Adrenergic Stimulation in Cobia (Rachycentron canadum)
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Oil Exposure Impairs In Situ Cardiac Function in Response to β-Adrenergic Stimulation in Cobia (Rachycentron canadum)

机译：暴露于油中会削弱军曹鱼（Rachycentron canadum）对β-肾上腺素能刺激的原位心脏功能

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摘要

Aqueous crude oil spills expose fish to varying concentrations of dissolved polycyclic aromatic hydrocarbons (PAHs), which can have lethal and sublethal effects. The heart is particularly vulnerable in early life stages, as PAH toxicity causes developmental cardiac abnormalities and impaired cardiovascular function. However, cardiac responses of juvenile and adult fish to acute oil exposure remain poorly understood. We sought to assess cardiac function in a pelagic fish species, the cobia (Rachycentron canadum), following acute (24 h) exposure to two ecologically I relevant levels of dissolved PAHs. Cardiac power output (CPO) was used to quantify cardiovascular performance using an in situ heart preparation. Cardiovascular performance was varied using multiple concentrations of the beta-adrenoceptor agonist isoproterenol (ISO) and by varying afterload pressures. Oil exposure adversely affected CPO with control fish achieving maximum CPO's (4 mW g(-1) Mv) greater than that of oil-exposed fish (1 mW g(-1) Mv) at ISO concentrations of 1 x 10(-6) M. However, the highest concentration of ISO (1 x 10(-5) M) rescued cardiac function. This indicates an interactive effect between oil-exposure and beta-adrenergic stimulation and suggests if animals achieve very large increases in beta-adrenergic stimulation it could play a compensatory role that may mitigate some adverse effects of oil exposure in vivo.
机译：原油溢水事故使鱼类暴露于不同浓度的溶解性多环芳烃（PAHs）中，这可能具有致命和亚致死作用。心脏在生命的早期阶段特别脆弱，因为PAH毒性会导致心脏发育异常和心血管功能受损。但是，关于幼鱼和成年鱼对急性油暴露的心脏反应仍知之甚少。我们试图评估急性（24小时）暴露于两种生态学上相关的可溶性多环芳烃水平后的中上层鱼类，即军曹鱼（Rachycentron canadum）的心脏功能。使用原位心脏制剂，将心脏功率输出（CPO）用于量化心血管功能。使用多种浓度的β-肾上腺素受体激动剂异丙肾上腺素（ISO）和改变后负荷压力来改变心血管性能。在ISO浓度为1 x 10（-6）的情况下，与控制鱼相比，暴露于油的鱼对CPO的影响最大，其最大CPO（4 mW g（-1）Mv）比接触油的鱼（1 mW g（-1）Mv）高。 M.但是，最高浓度的ISO（1 x 10（-5）M）可以挽救心脏功能。这表明了油脂接触和β-肾上腺素刺激之间的相互作用，并表明如果动物的β-肾上腺素刺激显着增加，它可以起到补偿作用，可以减轻体内油脂暴露的某些不利影响。

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  • 来源
    《Environmental Science & Technology》 |2017年第24期|14390-14396|共7页
  • 作者

    Cox Georgina K.; Crossley Dane A. II; Stieglitz John D.; Heuer Rachael M.; Benetti Daniel D.; Grosell Martin;

  • 作者单位

    Univ Miami, Dept Marine Biol & Ecol, Rosenstiel Sch Marine & Atmospher Sci, Miami, FL 33149 USA;

    Univ North Texas, Dept Biol Sci, 1155 Union Circle, Denton, TX 76203 USA;

    Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Dept Marine Ecosyst & Soc, Miami, FL 33149 USA;

    Univ Miami, Dept Marine Biol & Ecol, Rosenstiel Sch Marine & Atmospher Sci, Miami, FL 33149 USA;

    Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Dept Marine Ecosyst & Soc, Miami, FL 33149 USA;

    Univ Miami, Dept Marine Biol & Ecol, Rosenstiel Sch Marine & Atmospher Sci, Miami, FL 33149 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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