...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >New Insights into the Reliability of Automatic Dynamic Methods for Oral Bioaccessibility Testing: A Case Study for BGS102 soil
【24h】

New Insights into the Reliability of Automatic Dynamic Methods for Oral Bioaccessibility Testing: A Case Study for BGS102 soil

机译：口服生物可及性测试自动动态方法可靠性的新见解：以BGS102土壤为例

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dynamic flow-through extraction is attracting a great deal of attention for real-time monitoring of the bioaccessible fraction of metal species in environmental solid substrates compared to its batchwise manual counterparts. There is however a lack of studies on the harmonization and validation of in vitro dynamic methods for physiologically based extraction tests against in vivo bioavailability methods. This work is aimed at evaluating the reliability of dynamic flow-through extraction methods for estimation of oral bioaccessible fractions of Cu, Zn, Pb, Ni, Cr, and As under worst-case extraction conditions in the gastric compartment based on the BGS102 guidance soil using the in vivo validated Unified BARGE (UBM) test, commonly performed under batchwise mode. Good overall agreement between batch and dynamic UBM results was obtained for the tested elements, except for Pb, as a consequence of the slow leaching kinetics identified with the dynamic method and the contribution of readsorption phenomena in the course of the gastric digestion. Metal-soil phase associations and their relationship with gastric bioaccessible fractions were elucidated using the so-called Chemometric Identification of Substrates and Element Distributions method based on sequential extraction with a variety of chemicals of increasing acidity as applied to both static and dynamic bioaccessibility data.
机译：与分批手动操作相比，动态流通提取技术在实时监控环境固体基质中金属物种的生物可及成分方面引起了极大的关注。然而，缺乏针对基于体内生物利用度方法的基于生理学的提取测试的体外动态方法的协调和验证的研究。这项工作旨在评估基于BGS102指导土壤的最坏情况提取条件下动态流通法提取方法的可靠性，该方法可估算口腔中可吸收的Cu，Zn，Pb，Ni，Cr和As的生物可利用成分。使用体内验证的统一驳船（UBM）测试，通常在分批模式下执行。除了铅以外，对于测试元素，批次和动态UBM结果均获得了良好的总体一致性，这是由于采用动态方法鉴定的缓慢浸出动力学以及胃消化过程中再吸收现象的影响。使用所谓的化学底物和元素分布的化学计量学方法（基于顺序提取，使用各种增加酸度的化学物质，同时应用于静态和动态生物可及性数据），阐明了金属-土壤相的关联及其与胃可生物利用级分的关系。

著录项

  • 来源
    《Environmental Science & Technology》 |2016年第17期|9479-9486|共8页
  • 作者

    Mark R. Cave; Maria Rosende; Ian Mounteney; Amanda Gardner; Manuel Miro;

  • 作者单位

    British Geological Survey, Keyworth, Nottingham NG12 5GG, United Kingdom;

    FI-TRACE group, Department of Chemistry, University of the Balearic Islands, Carretera de Valldemossa km 7.5, 07122 Palma de Mallorca, Illes Balears, Spain;

    British Geological Survey, Keyworth, Nottingham NG12 5GG, United Kingdom;

    British Geological Survey, Keyworth, Nottingham NG12 5GG, United Kingdom;

    FI-TRACE group, Department of Chemistry, University of the Balearic Islands, Carretera de Valldemossa km 7.5, 07122 Palma de Mallorca, Illes Balears, Spain;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号