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首页> 外文期刊>Environmental Science & Technology >Highly Selective Screening of Estrogenic Compounds in Consumer-Electronics Plastics by Liquid Chromatography in Parallel Combined with Nanofractionation-Bioactivity Detection and Mass Spectrometry
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Highly Selective Screening of Estrogenic Compounds in Consumer-Electronics Plastics by Liquid Chromatography in Parallel Combined with Nanofractionation-Bioactivity Detection and Mass Spectrometry

机译：液相色谱与纳米级分-生物活性检测和质谱联用并行高效选择性筛选消费电子塑料中的雌激素化合物

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摘要

The chemical safety of consumer products is an issue of emerging concern. Plastics are widely used, e.g. as casings of consumer electronics (TVs, computers, routers, etc.), which are present in houses and offices in continuously increasing numbers. In this study, we investigate the estrogenic activity of components of plastics coming from electronics' casings. A recently developed fractionation platform for effect-directed analysis (EDA) was used. This platform combines reversed-phase liquid chromatography in parallel with bioassay detection via nanofractionation and with online high-resolution time-of-flight mass spectrometry (TOFMS) for the identification of bioactives. Four out of eight of the analyzed plastics samples showed the presence of estrogenic compounds. Based on the MS results these were assigned to bisphenol A (BPA), 2,4-di-tert-butylphenol, and a possible bisphenol A analog. All samples contained flame retardants, but these did not show any estrogenicity. The observed BPA, however, could be an impurity of tetrabromo-BPA (TBBPA) or TBBPA-based flame retardants. Due to the plausible migration of additives from plastics into the environment, plastics from consumer electronics likely constitute a source of estrogenic compound contamination in the indoor environment.
机译：消费品的化学安全性是一个日益受到关注的问题。塑料被广泛使用，例如作为消费类电子产品（电视，计算机，路由器等）的外壳，它们在房屋和办公室中的使用数量不断增加。在这项研究中，我们调查了来自电子设备外壳的塑料组件的雌激素活性。使用了最近开发的用于效果导向分析（EDA）的分级分离平台。该平台将反相液相色谱与通过纳米级分的生物测定检测以及在线高分辨率飞行时间质谱（TOFMS）结合使用，以鉴定生物活性物质。八分之四的分析塑料样品显示存在雌激素化合物。根据MS结果，将它们分配给双酚A（BPA），2,4-二叔丁基苯酚和可能的双酚A类似物。所有样品均包含阻燃剂，但没有显示出任何雌激素性。但是，观察到的BPA可能是四溴BPA（TBBPA）或TBBPA基阻燃剂的杂质。由于添加剂可能从塑料迁移到环境中，因此来自消费类电子产品的塑料可能构成室内环境中雌激素化合物污染的来源。

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  • 来源
    《Environmental Science & Technology》 |2016年第22期|12385-12393|共9页
  • 作者

    Willem Jonker; Ana Ballesteros-Gomez; Timo Hamers; Govert W. Somsen; Marja H. Lamoree; Jeroen Kool;

  • 作者单位

    Division of Bioanalytical Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands;

    Institute for Environmental Studies, Vrij Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands;

    Institute for Environmental Studies, Vrij Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands;

    Division of Bioanalytical Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands;

    Institute for Environmental Studies, Vrij Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands;

    Division of Bioanalytical Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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