...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Accumulation Dynamics and Acute Toxicity of Silver Nanoparticles to Daphnia magna and Lumbriculus variegatus: Implications for Metal Modeling Approaches
【24h】

Accumulation Dynamics and Acute Toxicity of Silver Nanoparticles to Daphnia magna and Lumbriculus variegatus: Implications for Metal Modeling Approaches

机译：银纳米粒子对水蚤和卷柏的累积动力学和急性毒性：对金属建模方法的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Frameworks commonly used in trace metal ecotoxicology (e.g., biotic ligand model (BLM) and tissue residue approach (TRA)) are based on the established link between uptake, accumulation and toxicity, but similar relationships remain unverified for metal-containing nanoparticles (NPs). The present study aimed to (ⅰ) characterize the bioaccumulation dynamics of PVP-, PEG-, and citrate-AgNPs, in comparison to dissolved Ag, in Daphnia magna and Lumbriculus variegatus; and (ⅱ) investigate whether parameters of bioavailability and accumulation predict acute toxicity. In both species, uptake rate constants for AgNPs were ～2-10 times less than for dissolved Ag and showed significant rank order concordance with acute toxicity. Ag elimination by L. variegatus fitted a 1-compartment loss model, whereas elimination in D. magna was biphasic. The latter showed consistency with studies that reported daphnids ingesting NPs, whereas L. variegatus biodynamic parameters indicated that uptake and efflux were primarily determined by the bioavailability of dissolved Ag released by the AgNPs. Thus, principles of BLM and TRA frameworks are confounded by the feeding behavior of D. magna where the ingestion of AgNPs perturbs the relationship between tissue concentrations and acute toxicity, but such approaches are applicable when accumulation and acute toxicity are linked to dissolved concentrations. The uptake rate constant, as a parameter of bioavailability inclusive of all available pathways, could be a successful predictor of acute toxicity.
机译：痕量金属生态毒理学中常用的框架（例如，生物配体模型（BLM）和组织残留方法（TRA））基于摄取，积累和毒性之间的既定联系，但是对于含金属的纳米颗粒（NP），相似的关系仍未得到证实。本研究旨在（ⅰ）表征大型蚤（Daphnia magna）和变异型狼疮（Lumbriculus variegatus）中PVP-，PEG-和柠檬酸盐-AgNPs与溶解的Ag相比的生物蓄积动力学； （ⅱ）研究生物利用度和蓄积参数是否可预测急性毒性。在这两个物种中，AgNPs的吸收速率常数都比溶解性Ag的约2-10倍，并且显示出与急性毒性显着的等级次序一致性。百日咳杆菌消除银符合1-室损失模型，而D. magna消除则是双相的。后者显示了与报道水蚤摄入NPs的研究一致的结果，而美洲乳杆菌的生物力学参数表明摄取和外排主要取决于由AgNPs释放的溶解Ag的生物利用度。因此，BLM和TRA框架的原理与D.magna的摄食行为相混淆，在该行为中，AgNP的摄入扰乱了组织浓度与急性毒性之间的关系，但是当蓄积和急性毒性与溶解浓度相关时，这些方法适用。吸收速率常数作为包括所有可用途径在内的生物利用度的参数，可能是急性毒性的成功预测指标。

著录项

  • 来源
    《Environmental Science & Technology》 |2015年第7期|4389-4397|共9页
  • 作者

    Farhan R. Khan; Kai B. Paul; Agnieszka D. Dybowska; Eugenia Valsami-Jones; Jamie R. Lead; Vicki Stone; Teresa F. Fernandes;

  • 作者单位

    School of Life Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom,Department of Environmental, Social and Spatial Change, Roskilde University, Universitetsvej 1, PO Box 260, DK-4000 Roskilde, Denmark;

    School of Life Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom;

    Earth Sciences, Natural History Museum, Cromwell Road, London SW7 5BD, England;

    School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, England;

    SmartState Center for Environmental Nanoscience and Risk (CENR), Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29088, United States;

    School of Life Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom;

    School of Life Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号