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首页> 外文期刊>Environmental Science & Technology >Toxicity Assessment of 4-Methyl-1 -cyclohexanemethanol and Its Metabolites in Response to a Recent Chemical Spill in West Virginia, USA
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Toxicity Assessment of 4-Methyl-1 -cyclohexanemethanol and Its Metabolites in Response to a Recent Chemical Spill in West Virginia, USA

机译：在美国西弗吉尼亚州发生的化学泄漏对4-甲基-1-环己烷甲醇及其代谢物的毒性评估

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摘要

The large-scale chemical spill on January 9, 2014 from coal processing and cleaning storage tanks of Freedom Industries in Charleston affected the drinking water supply to 300,000 people in Charleston, West Virginia metropolitan, while the short-term and long-term health impacts remain largely unknown and need to be assessed and monitored. There is a lack of publically available toxicological information for the main contaminant 4-methyl-1-cyclo- hexanemethanol (4-MCHM). Particularly, little is known about 4-MCHM metabolites and their toxicity. This study reports timely and original results of the mechanistic toxicity assessment of 4-MCHM and its metabolites via a newly developed quantitative toxicogenomics approach, employing proteomics analysis in yeast cells and transcriptional analysis in human cells. These results suggested that, although 4-MCHM is considered only moderately toxic based on the previous limited acute toxicity evaluation, 4-MCHM metabolites were likely more toxic than 4-MCHM in both yeast and human cells, with different toxicity profiles and potential mechanisms. In the yeast library, 4-MCHM mainly induced chemical stress related to transmembrane transport and transporter activity, while 4-MCHM metabolites of S9 mainly induced oxidative stress related to antioxidant activity and oxidoreductase activity. With human A549 cells, 4-MCHM mainly induced DNA damage-related biomarkers, which indicates that 4-MCHM is related to genotoxicity due to its DNA damage effect on human cells and therefore warrants further chronic carcinogenesis evaluation.
机译：2014年1月9日，查尔斯顿Freedom Industries的煤炭加工和清洁储罐发生大规模化学泄漏，影响了西弗吉尼亚大都市查尔斯顿30万人的饮用水供应，而短期和长期健康影响仍然存在很大程度上未知，需要进行评估和监视。对于主要污染物4-甲基-1-环己烷甲醇（4-MCHM），缺乏公开的毒理学信息。特别是4-MCHM代谢物及其毒性知之甚少。这项研究报告了新的定量毒理基因组学方法，采用了酵母细胞中的蛋白质组学分析和人类细胞中的转录分析，对4-MCHM及其代谢物进行了机械毒性评估，获得了及时而原始的结果。这些结果表明，尽管根据先前的有限急性毒性评估，仅将4-MCHM视为中度毒性，但在酵母和人细胞中，4-MCHM代谢物的毒性可能比4-MCHM更高，具有不同的毒性谱和潜在机制。在酵母文库中，4-MCHM主要诱导与跨膜转运和转运蛋白活性相关的化学应激，而S9的4-MCHM代谢产物主要诱导与抗氧化活性和氧化还原酶活性相关的氧化应激。对于人A549细胞，4-MCHM主要诱导DNA损伤相关的生物标志物，这表明4-MCHM由于其对人细胞的DNA损伤作用而与遗传毒性有关，因此值得进一步进行慢性致癌性评估。

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  • 来源
    《Environmental Science & Technology》 |2015年第10期|6284-6293|共10页
  • 作者

    Jiaqi Lan; Man Hu; Ce Gao; Akram Alshawabkeh; April Z. Gu;

  • 作者单位

    Department of Civil and Environmental Engineering, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States;

    Department of Civil and Environmental Engineering, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States;

    Department of Civil and Environmental Engineering, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States;

    Department of Civil and Environmental Engineering, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States;

    Department of Civil and Environmental Engineering, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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