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首页> 外文期刊>Environmental Science & Technology >Association between Several Persistent Organic Pollutants in Serum and Adipokine Levels in Breast Milk among Lactating Women of Korea
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Association between Several Persistent Organic Pollutants in Serum and Adipokine Levels in Breast Milk among Lactating Women of Korea

机译：哺乳期妇女血清中几种持久性有机污染物与母乳中脂肪含量之间的关联

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摘要

Exposure to several persistent organic pollutants (POPs) has been linked to alteration of lipid metabolism. Adipokines, such as leptin and adiponectin, are hormones that play roles in lipid metabolism, and have been suggested as markers of health effects that may lead to obesity. To date, only serum adipokines have been associated with POPs exposure. In the present study, for the first time, the associations between leptin and adiponectin in breast milk, and several POPs in serum were investigated among 82 lactating Korean women between 25 and 46 years of age. Breast milk adipokines are important because adipokine intake of infant through breastfeeding may influence the growth of infants. The median concentrations of leptin and adiponectin in skimmed milk of the Korean lactating women were 17.9 ng/L and 16.5 μg/L, respectively. Leptin concentrations in breast milk were negatively associated with Σhexachlorohexane (HCH), oxychlordane, Σchlordane, or 2,2',4,4',5,5'-hexachlorobiphenyl (CB 153) levels in maternal serum. Linear relationships between adiponectin and POPs concentrations were not observed, however, nonmonotonic relationship which showed generally positive associations was suggested for p,p'~ dichlorodiphenyltrichloroethane (DDT) and Σchlordane in quartile analysis. Our observations show that POPs at the current level of exposure may be associated with the alteration of lipid metabolism among lactating women. Implication of adipokine transfer to breastfed infants is of concern and deserves further investigation.
机译：暴露于几种持久性有机污染物（POPs）与脂质代谢的改变有关。诸如瘦素和脂联素之类的脂肪因子是在脂质代谢中起作用的激素，已被建议作为可能导致肥胖的健康影响的标志物。迄今为止，只有血清脂肪因子与POPs暴露有关。在本研究中，首次调查了82名25岁至46岁的哺乳期韩国妇女中母乳中瘦素和脂联素之间的关联以及血清中的几种持久性有机污染物。母乳脂肪因子很重要，因为通过母乳喂养婴儿摄入的脂肪因子可能会影响婴儿的生长。韩国哺乳期妇女脱脂牛奶中的瘦素和脂联素的中位数浓度分别为17.9 ng / L和16.5μg/ L。母乳中的瘦素浓度与孕妇血清中的六氯己烷（HCH），氧氯丹，Σ氯丹或2,2'，4,4'，5,5'-六氯联苯（CB 153）水平呈负相关。在四分位数分析中，未观察到脂联素与POPs浓度之间的线性关系，但非单调关系通常显示p，p'〜二氯二苯基三氯乙烷（DDT）和∑氯丹呈正相关。我们的观察结果表明，当前暴露水平的持久性有机污染物可能与哺乳期妇女脂质代谢的改变有关。将脂肪因子转移给母乳喂养的婴儿是值得关注的，值得进一步研究。

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  • 来源
    《Environmental Science & Technology》 |2015年第13期|8033-8040|共8页
  • 作者

    Sunmi Kim; Jeongim Park; Hai-Joong Kim; Jeong Jae Lee; Gyuyeon Choi; Sooran Choi; Sungjoo Kim; Su Young Kim; Duk Hee Lee; Hyo-Bang Moon; Sungkyoon Kim; Kyungho Choi;

  • 作者单位

    School of Public Health, Seoul National University, Seoul 151-742, Republic of Korea;

    College of Natural Sciences, Soonchunhyang University, Asan 336-745, Republic of Korea;

    College of Medicine, Korea University, Seoul 152-703, Republic of Korea;

    College of Medicine, Soonchunhyang University, Seoul 140-743, Republic of Korea;

    College of Medicine, Soonchunhyang University, Seoul 140-743, Republic of Korea;

    College of Medicine, Inha University, Incheon 400-711, Republic of Korea;

    College of Medicine, Hallym University, Anyang 431-796, Republic of Korea;

    College of Medicine, Jeju National University, Jeju 690-756, Republic of Korea;

    College of Medicine, Kyungpook National University, Daegu 700-721, Republic of Korea;

    College of Science and Technology, Hanyang University, Ansan 426-791, Republic of Korea;

    School of Public Health, Seoul National University, Seoul 151-742, Republic of Korea;

    School of Public Health, Seoul National University, Seoul 151-742, Republic of Korea;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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