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首页> 外文期刊>Environmental Science & Technology >Detection and Quantification of Benzothiazoles in Exhaled Breath and Exhaled Breath Condensate by Real-Time Secondary Electrospray Ionization-High-Resolution Mass Spectrometry and Ultra-High Performance Liquid Chromatography
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Detection and Quantification of Benzothiazoles in Exhaled Breath and Exhaled Breath Condensate by Real-Time Secondary Electrospray Ionization-High-Resolution Mass Spectrometry and Ultra-High Performance Liquid Chromatography

机译：实时二次电喷雾电离高分辨质谱和超高效液相色谱法检测和定量呼出气和呼出气冷凝物中的苯并噻唑

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摘要

2-Subtituted benzothiazoles are widely used industrial chemicals whose occurrence in environmental samples has been shown to be ubiquitous. However, knowledge about human exposure to these compounds and their excretion route is still scarce. Here, we demonstrate for the first time the detection of benzothiazole derivatives in exhaled breath. Real-time analysis of breath was carried out by means of secondary electrospray ionization coupled to high-resolution mass spectrometry. This coupling allowed not only the detection of these compounds in breath with a sensitivity in the pptv range but also their robust identification by comparing tandem high-resolution mass spectra from breath and standards. For further confirmation, benzothiazoles were also determined in exhaled breath condensate samples by means of ultra high-performance liquid chromatography. This approach strengthened the identification as a result of excellent matches in retention times and also allowed quantification. An estimated total daily exhalation of ca. 20 μg day~(-1) was calculated for the six benzothiazole derivatives found in breath.
机译：2-取代的苯并噻唑是广泛使用的工业化学品，其在环境样品中的存在已被证明是普遍存在的。但是，关于人类暴露于这些化合物及其排泄途径的知识仍然很少。在这里，我们首次展示了呼出气中苯并噻唑衍生物的检测。呼吸的实时分析是通过与高分辨率质谱联用的二次电喷雾电离进行的。这种耦合不仅允许以pptv范围的灵敏度检测呼吸中的这些化合物，而且还可以通过比较来自呼吸和标准品的串联高分辨率质谱图对它们进行可靠的鉴定。为进一步确认，还通过超高效液相色谱法测定了呼出气冷凝物样品中的苯并噻唑。由于保留时间的出色匹配，这种方法加强了鉴定，并且还可以进行定量分析。估计每天的总呼出量约为对于呼吸中发现的六种苯并噻唑衍生物，计算出20μgday〜（-1）。

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  • 来源
    《Environmental Science & Technology》 |2015年第20期|12519-12524|共6页
  • 作者

    Diego Garcia-Gomez; Lukas Bregy; Yvonne Nussbaumer-Ochsner; Thomas Gaisl; Malcolm Kohler; Renato Zenobi;

  • 作者单位

    Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland;

    Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland;

    Pulmonary Division, University Hospital Zurich, CH-8091 Zurich, Switzerland;

    Pulmonary Division, University Hospital Zurich, CH-8091 Zurich, Switzerland;

    Pulmonary Division, University Hospital Zurich, CH-8091 Zurich, Switzerland;

    Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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