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首页> 外文期刊>Environmental Science & Technology >Differential Toxicokinetics Determines the Sensitivity of Two Marine Embryonic Fish Exposed to Iranian Heavy Crude Oil
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Differential Toxicokinetics Determines the Sensitivity of Two Marine Embryonic Fish Exposed to Iranian Heavy Crude Oil

机译：差异毒物动力学确定暴露于伊朗重质原油中的两种海洋胚胎鱼的敏感性

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摘要

Interspecific difference in the developmental toxicity of crude oil to embryonic fish allows the prediction of injury extent to a number of resident fish species in oil spill sites. This study clarifies the comparative developmental effects of banian heavy crude oil (IHCO) on the differences of biouptake and toxic sensitivity between embryonic spotted sea bass (Lateolabrax maculates) and olive Sounder (Paralichthys olivaceus). From 24 h after exposure to IHCO, several morphological defects were observed in both species of embryonic fish, including pericardial edema, dorsal curvature of the trunk, developmental delay, and reduced finfolds. The severity of defects was greater in flounder compared to that in sea bass. While flounder embryos accumulated higher embryo PAH concentrations than sea bass, the former showed significantly lower levels of CYP1A expression. Although bioconcentration ratios were similar between the two species for some PAHs, phenanthrenes and dibenzothiophenes showed selectively higher bioconcentration ratios in flounder, suggesting that this species has a reduced metabolic capacity for these compounds. While consistent with a conserved cardiotoxic mechanism for petrogenic PAHs across diverse marine and freshwater species, these findings indicate that species-specific differences in toxicokinetics can be an important factor underlying species' sensitivity to crude oil.
机译：原油对胚鱼的发育毒性之间的种间差异可以预测溢油场所中许多常驻鱼类的伤害程度。这项研究阐明了巴尼亚重质原油（IHCO）对有斑点的鲈鱼（Lateolabrax maculates）和橄榄Sounder（Paralichthys olivaceus）的生物摄取和毒性敏感性差异的比较发展作用。从暴露于IHCO的24小时起，在两种胚胎鱼中都观察到了几种形态学缺陷，包括心包水肿，躯干背侧弯曲，发育迟缓和减少的褶皱。比起鲈鱼，比目鱼的缺陷严重程度更高。虽然比目鱼的胚胎积累的PAH浓度高于海鲈，但前者的CYP1A表达水平明显降低。尽管对于某些PAH，两个物种之间的生物浓度比相似，但是菲和二苯并噻吩在比目鱼中显示出更高的生物浓度比，这表明该物种对这些化合物的代谢能力降低。这些发现与跨海洋和淡水物种的成岩多环芳烃的保守心脏毒性机制一致，但这些发现表明毒物动力学的物种特异性差异可能是物种对原油敏感性的重要因素。

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  • 来源
    《Environmental Science & Technology》 |2015年第22期|13639-13648|共10页
  • 作者

    Jee-Hyun Jung; Moonkoo Kim; Un Hyuk Yim; Sung Yong Ha; Won Joon Shim; Young Sun Chae; Hana Kim; John P. Incardona; Tiffany L. Linbo; Jung-Hwan Kwon;

  • 作者单位

    Oil & POPs Research Group, Korea Institute of Ocean Science & Technology, 41 Jangmokl-gil Geoje, 53201, Korea;

    Oil & POPs Research Group, Korea Institute of Ocean Science & Technology, 41 Jangmokl-gil Geoje, 53201, Korea;

    Oil & POPs Research Group, Korea Institute of Ocean Science & Technology, 41 Jangmokl-gil Geoje, 53201, Korea;

    Oil & POPs Research Group, Korea Institute of Ocean Science & Technology, 41 Jangmokl-gil Geoje, 53201, Korea;

    Oil & POPs Research Group, Korea Institute of Ocean Science & Technology, 41 Jangmokl-gil Geoje, 53201, Korea;

    Oil & POPs Research Group, Korea Institute of Ocean Science & Technology, 41 Jangmokl-gil Geoje, 53201, Korea;

    Oil & POPs Research Group, Korea Institute of Ocean Science & Technology, 41 Jangmokl-gil Geoje, 53201, Korea;

    Environmental and Fisheries Science Division, Northwest Fisheries Science Center, National Marine Fisheries Service (NOAA), 2725 Montlake Boulevard East, Seattle, Washington 98112 United States;

    Environmental and Fisheries Science Division, Northwest Fisheries Science Center, National Marine Fisheries Service (NOAA), 2725 Montlake Boulevard East, Seattle, Washington 98112 United States;

    Division of Environmental Science and Ecological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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