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In Vivo Tracing Uptake and Elimination of Organic Pesticides in Fish Muscle

机译：体内追踪吸收和消除鱼肌肉中有机农药

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摘要

Bioconcentration factors (BCFs) measured in the laboratory are important for characterizing the bioaccumu-lative properties of chemicals entering the environment, especially the potential persistent organic pollutants (POPs), which can pose serious adverse effects on ecosystem and human health. Traditional lethal analysis methods are time-consuming and sacrifice too many experimental animals. In the present study, in vivo solid-phase microextraction (SPME) was introduced to trace the uptake and elimination processes of pesticides in living fish. BCFs and elimination kinetic coefficients of the pesticides were recorded therein. Moreover, the metabolism of fenthion was also traced with in vivo SPME. The method was time-efficient and laborsaving. Much fewer experimental animals were sacrificed during the tracing. In general, this study opened up an opportunity to measure BCFs cheaply in laboratories for the registering of emerging POPs and inspecting of suspected POPs, as well as demonstrated the potential application of in vivo SPME in the study of toxicokinetics of pollutants.
机译：在实验室中测量的生物富集系数（BCF）对于表征进入环境的化学物质的生物蓄积特性非常重要，尤其是潜在的持久性有机污染物（POPs），这会对生态系统和人类健康造成严重的不利影响。传统的致死分析方法既耗时又牺牲太多实验动物。在本研究中，引入了体内固相微萃取（SPME）来追踪活鱼中农药的吸收和消除过程。记录了农药的生物浓缩系数和消除动力学系数。此外，体内SPME还可以追踪到硫磷的代谢。该方法省时省力。在追踪过程中牺牲了更少的实验动物。总的来说，这项研究为在实验室中廉价地测量BCFs提供了机会，用于注册新兴的POPs和检查可疑的POPs，并证明了体内SPME在污染物毒物动力学研究中的潜在应用。

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  • 来源
    《Environmental Science & Technology》 |2014年第14期|8012-8020|共9页
  • 作者

    Jianqiao Xu; Junpeng Luo; Jingwen Ruan; Fang Zhu; Tiangang Luan; Hong Liu; Ruifen Jiang; Gangfeng Ouyang;

  • 作者单位

    MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275 Guangdong, China;

    MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275 Guangdong, China;

    MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275 Guangdong, China;

    MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275 Guangdong, China;

    MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275 Guangdong, China;

    MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275 Guangdong, China;

    MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275 Guangdong, China;

    MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275 Guangdong, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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