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首页> 外文期刊>Environmental Science & Technology >Exposure to Mutagenic Disinfection Byproducts Leads to Increase of Antibiotic Resistance in Pseudomonas aeruginosa
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Exposure to Mutagenic Disinfection Byproducts Leads to Increase of Antibiotic Resistance in Pseudomonas aeruginosa

机译：暴露于诱变消毒副产物导致铜绿假单胞菌对抗生素的耐药性增加

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摘要

Bacterial antibiotic resistance (BAR) in drinking water has become a global issue because of its risks on the public health. Usually, the antibiotic concentrations in drinking water are too low to select antibiotic resistant strains effectively, suggesting that factors other than antibiotics would contribute to the emergence of BAR. In the current study, the impacts of mutagenic disinfection byproducts (DBPs) on BAR were explored, using four typical DBPs: dibromoacetic acid, dichloroacetonitrile, potassium bromate, and 3-chloro-4-(dichloromethyl)-5-hydrozy-2(5H)-furanone (MX). After exposure to DBPs, resistances to 10 individual antibiotics and multiple antibiotics were both raised by various levels, norfloxacin and polymycin B resistances were enhanced even greater than 10-fold compared with control. MX increased the resistance most observably in the selected DBPs, which was consistent with its mutagenic activity. The resistant mutants showed hereditary stability during 5-day culturing. The increase of BAR was caused by the mutagenic activities of DBPs, since mutation frequency declined by adding ROS scavenger. Mutagenesis was further confirmed by sequencing of the related genes. Our study indicated that mutagenic activities of the selected DBPs could induce antibiotic resistance, even multidrug resistance, which may partially explain the lack of agreement between BAR and antibiotic levels in drinking water.
机译：饮用水中的细菌抗生素抗性（BAR）由于其对公共健康的风险而成为全球性问题。通常，饮用水中的抗生素浓度过低，无法有效选择抗药性菌株，这表明除抗生素以外的其他因素也会导致BAR的出现。在本研究中，使用四种典型的DBP探索了诱变消毒副产物（DBP）对BAR的影响：二溴乙酸，二氯乙腈，溴酸钾和3-氯-4-（二氯甲基）-5-氢-2（5H） ）-呋喃酮（MX）。暴露于DBPs后，对10种个体抗生素和多种抗生素的耐药性均以不同水平提高，与对照相比，诺氟沙星和多霉素B的耐药性甚至提高了10倍以上。 MX在选定的DBP中最明显地增加了抗性，这与其诱变活性是一致的。抗性突变体在5天的培养过程中显示出遗传稳定性。 BAR的增加是由DBP的诱变活性引起的，因为加入ROS清除剂后突变频率降低了。通过相关基因的测序进一步证实了诱变。我们的研究表明，所选DBPs的诱变活性可以诱导抗生素耐药性，甚至产生多药耐药性，这可以部分解释饮用水中BAR与抗生素水平之间缺乏一致性。

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  • 来源
    《Environmental Science & Technology》 |2014年第14期|8188-8195|共8页
  • 作者

    Lu Lv; Tao Jiang; Shenghua Zhang; Xin Yu;

  • 作者单位

    Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, People's Republic of China;

    Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, People's Republic of China;

    Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, People's Republic of China;

    Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, People's Republic of China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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