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首页> 外文期刊>Environmental Science & Technology >Feeding Activity and Xenobiotics Modulate Oxidative Status in Daphnia magna: Implications for Ecotoxicological Testing
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Feeding Activity and Xenobiotics Modulate Oxidative Status in Daphnia magna: Implications for Ecotoxicological Testing

机译：捕食活动和异质生物调节大水蚤的氧化状态：对生态毒理学测试的影响。

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摘要

To apply biomarkers of oxidative stress in laboratory and field settings, an understanding of their responses to changes in physiological rates is important. The evidence is accumulating that caloric intake can increase production of reactive oxygen species and thus affect background variability of oxidative stress biomarkers in ecotoxicological testing. This study aimed to delineate effects of food intake and xenobiotics on oxidative biomarkers in Daphnia magna. Antioxidant capacity measured as oxygen radical absorbance capacity (ORAC) and lipid peroxidation assayed as thiobarbituric acid reactive substances (TBARS) were measured. Food intake was manipulated by varying food densities or by exposing the animals to chemicals inhibiting feeding rate (pharmaceutical haloperidol and pesticide lindane). Feeding rate proved to affect both protein, ORAC, and TBARS in unexposed daphnids. However, there was no significant effect of feeding rate on the protein-specific ORAC values. Both substances affected individual protein and ORAC levels and changed their relationship to feeding rate. Our results show that inhibition of feeding rate influenced the interpretation of biomarker response and further emphasize the importance of understanding (1) baseline variability in potential biomarkers due to variations in metabolic state and (2) the contribution of feeding rate on toxic response of biomarkers.
机译：为了在实验室和野外环境中应用氧化应激的生物标记，重要的是要了解它们对生理速率变化的反应。越来越多的证据表明，摄入热量可以增加活性氧的产生，从而影响生态毒理学测试中氧化应激生物标志物的背景变异性。这项研究旨在描述食物摄入和异种生物素对水蚤的氧化生物标志物的影响。测量了作为氧自由基吸收能力（ORAC）测得的抗氧化能力和作为硫代巴比妥酸反应性物质（TBARS）测得的脂质过氧化。通过改变食物密度或使动物接触抑制进食速度的化学药品（氟哌啶醇和农药林丹）来控制食物的摄入。事实证明，喂食速度会影响未暴露水蚤的蛋白质，ORAC和TBARS。但是，进食速度对蛋白质特异性ORAC值没有显着影响。两种物质都会影响蛋白质和ORAC的水平，并改变它们与摄食率的关系。我们的结果表明，进食速率的抑制影响了生物标志物应答的解释，并进一步强调了理解的重要性（1）由于代谢状态的变化，潜在生物标志物的基线变异性；（2）进食速率对生物标志物毒性反应的贡献。

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  • 来源
    《Environmental Science & Technology》 |2014年第21期|12886-12892|共7页
  • 作者

    Sara Furuhagen; Birgitta Liewenborg; Magnus Breitholtz; Elena Gorokhova;

  • 作者单位

    Department of Applied Environmental Science, Stockholm University, Svante Arrhenius vaeg 8, SE-106 91 Stockholm, Sweden;

    Department of Applied Environmental Science, Stockholm University, Svante Arrhenius vaeg 8, SE-106 91 Stockholm, Sweden;

    Department of Applied Environmental Science, Stockholm University, Svante Arrhenius vaeg 8, SE-106 91 Stockholm, Sweden;

    Department of Applied Environmental Science, Stockholm University, Svante Arrhenius vaeg 8, SE-106 91 Stockholm, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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