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首页> 外文期刊>Environmental Science & Technology >Acid-Catalyzed Transformation of lonophore Veterinary Antibiotics: Reaction Mechanism and Product Implications
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Acid-Catalyzed Transformation of lonophore Veterinary Antibiotics: Reaction Mechanism and Product Implications

机译：酸催化长春新兽类抗生素的转化：反应机理和产物含义

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摘要

Ionophore antibiotics (IPAs) are polyether antimicrobials widely used in the livestock industry and may enter the environment via land application of animal waste and agricultural runoff. Information is scarce regarding potential transformation of IPAs under environmental conditions. This study is among the first to identify the propensity of IPAs to undergo acid-catalyzed transformation in mildly acidic aquatic systems and characterize the reactions in depth. The study focused on the most widely used monensin (MON) and salinomycin (SAL), and also included narasin (NAR) in the investigation. All three IPAs are susceptible to acid-catalyzed transformation. MON reacts much more slowly than SAL and NAR and exhibits a different kinetic behavior that is further evaluated by a reversible reaction kinetic model. Extensive product characterization identifies that the spiro-ketal group of IPAs is the reactive site for the acid-catalyzed hydrolytic transformation, yielding predominantly isomeric and other products. Toxicity evaluation of the transformation products shows that the products retain some antimicrobial properties. The occurrence of IPAs and isomeric transformation products is also observed in poultry litter and agricultural runoff samples. Considering the common presence of mildly acidic environments (pH 4-7) in soils and waters, the acid-catalyzed transformation identified in this study likely plays an important role in the environmental fate of IPAs.
机译：离子载体抗生素（IPA）是在畜牧业中广泛使用的聚醚类抗菌剂，可能通过土地利用，动物粪便和农业径流进入环境。关于在环境条件下IPA可能发生的转变的信息很少。这项研究是首次确定IPA在轻度酸性水生系统中发生酸催化转化并深入表征反应的倾向。该研究集中于最广泛使用的莫能菌素（MON）和盐霉素（SAL），并且还包括了奈拉菌素（NAR）。所有三个IPA都容易受到酸催化的转化。 MON的反应比SAL和NAR慢得多，并且表现出不同的动力学行为，可逆反应动力学模型进一步评估了该动力学行为。广泛的产物表征表明，IPA的螺缩酮基是酸催化水解转化的反应位点，主要产生异构体和其他产物。转化产物的毒性评估表明，该产物保留了某些抗菌性能。在家禽垫料和农业径流样品中也观察到IPA和异构体转化产物的出现。考虑到土壤和水中普遍存在弱酸性环境（pH 4-7），本研究中确定的酸催化转化可能在IPA的环境命运中发挥重要作用。

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  • 来源
    《Environmental Science & Technology》 |2013年第13期|6781-6789|共9页
  • 作者

    Peizhe Sun; Hong Yao; Daisuke Minakata; John C. Crittenden; Spyros G. Pavlostathis; Ching-Hua Huang;

  • 作者单位

    School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States;

    School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States,Department of Municipal and Environmental Engineering, Beijing Jiaotong University, Beijing, 100044, People's Republic of China;

    School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States,Brook Byers Institute for Sustainable Systems, Georgia Institute of Technology, Atlanta, Georgia 30332, United States;

    School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States,Brook Byers Institute for Sustainable Systems, Georgia Institute of Technology, Atlanta, Georgia 30332, United States;

    School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States;

    School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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