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Evaluating the Transcriptomic and Metabolic Profile of Mice Exposed to Source Drinking Water

机译：评价暴露于源饮用水的小鼠的转录组和代谢谱

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摘要

Transcriptomic and metabonomk methods were used to investigate mice's responses to drinking source water (DSW) exposure. After mice were fed with DSW for 90 days, hepatic transcriptome was characterized by mjcroarray and serum metabonome were determined by *H nuclear magnetic resonance (NMR) spectroscopy. A total of 243 differentially expressed genes (DEGs) were identified, among which 141 genes were up-regulated and 102 genes were down-regulated. Metabonomics revealed significant changes in concentrations of creatine, pyruvate, glutamine, lysine, choline, acetate, lipids, tanrine, and trimethylamine oxide. Four biological pathways were identified by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis where both gene expression and metabolite concentrations were altered in response to DSW exposure. These results highlight the significance of combined use of transcriptomic and metabo- nomk approaches in evaluating potential health risk induced by DSW contaminated with various hazardous materials.
机译：转录组学和代谢酶学方法用于研究小鼠对饮用水源（DSW）暴露的反应。用DSW喂养小鼠90天后，通过微阵列对肝转录组进行表征，并通过* H核磁共振（NMR）光谱测定血清代谢组学。总共鉴定了243个差异表达基因（DEG），其中141个基因被上调，而102个基因被下调。代谢组学揭示了肌酸，丙酮酸，谷氨酰胺，赖氨酸，胆碱，乙酸盐，脂质，鞣质和三甲基氧化胺浓度的显着变化。京都基因与基因组百科全书（KEGG）途径分析确定了四种生物学途径，其中基因表达和代谢物浓度均响应DSW暴露而改变。这些结果突出了转录组学和代谢组学方法联合使用在评估由各种有害物质污染的DSW引起的潜在健康风险中的重要性。

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  • 来源
    《Environmental Science & Technology》 |2012年第1期|p.78-83|共6页
  • 作者

    Yan Zhang; Xuxiang Zhang; Bing Wu; Shupei Cheng;

  • 作者单位

    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210046, China;

    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210046, China;

    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210046, China;

    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210046, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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