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首页> 外文期刊>Environmental Science & Technology >Distribution of Functionalized Gold Nanoparticles between Water and Lipid Bilayers as Model Cell Membranes
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Distribution of Functionalized Gold Nanoparticles between Water and Lipid Bilayers as Model Cell Membranes

机译：水和脂质双层作为模型细胞膜之间的功能化金纳米粒子的分布。

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摘要

Lipid bilayers are biomembranes common to cellular life and constitute a continuous barrier between cells and their environment. Understanding the interaction of nanoparticles with lipid bilayers is an important step toward predicting subsequent biological effects. In this study, we assessed the affinity of functionalized gold nanoparticles (Au NPs) with sizes from 5 to 100 nm to lipid bilayers by determining the Au NP distribution between aqueous electrolytes and lipid bilayers. The Au NP distribution to lipid bilayers reached an apparent steady state in 24 h with smaller Au NPs distributing onto lipid bilayers more rapidly than larger ones. Au NPs distributed to lipid bilayers to a larger extent at lower pH. Tannic acid-iunctionalized Au NPs exhibited greater distribution to lipid bilayers than polyvinylpyrrolidone-funcrionalized Au NPs of the same size. Across the various Au NP sizes, we measure the lipid bilayer-water distribution coefficient (Kfcw = Cup/O as 450 L/kg lipid, which is independent of dosimetric units. This work suggests that the nanopartide-cell membrane interaction is dependent on solution chemistry and nanopartide surface functionality. The KBpw value may be used to predict the affinity of spherical Au NPs across a certain size range toward lipid membranes.
机译：脂质双层是细胞生命中常见的生物膜，构成细胞与其环境之间的连续屏障。了解纳米颗粒与脂质双层的相互作用是预测后续生物学效应的重要一步。在这项研究中，我们通过确定水性电解质和脂质双层之间的Au NP分布，评估了大小为5至100 nm的功能化金纳米颗粒（Au NP）与脂质双层的亲和力。 Au NP在脂双层中的分布在24小时内达到了明显的稳态，较小的Au NP比较大的Au NP更快地分布在脂质双层上。在较低的pH下，金纳米颗粒较大程度地分布在脂质双层上。与相同大小的聚乙烯吡咯烷酮官能化的金纳米粒子相比，单宁酸官能化的金纳米粒子在脂质双层中的分布更大。在各种金纳米颗粒尺寸上，我们测量脂质双层-水的分配系数（Kfcw =杯/ O为450 L / kg脂质，与剂量单位无关），这项工作表明纳米粒子-细胞膜相互作用取决于溶液。 KBpw值可用于预测一定尺寸范围内球形Au NPs对脂质膜的亲和力。

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  • 来源
    《Environmental Science & Technology》 |2012年第3期|p.1869-1876|共8页
  • 作者

    Wen-Che Hou; Babak Yaghoubi Moghadam; Charlie Corrector; Paul Westerhoff; Jonathan D. Posner;

  • 作者单位

    School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, Arizona 85287-5306, United States;

    Mechanical Engineering, Chemical Engineering, University of Washington, Seattle, Washington 98195-2600, United States;

    Mechanical Engineering, Chemical Engineering, University of Washington, Seattle, Washington 98195-2600, United States;

    School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, Arizona 85287-5306, United States;

    Mechanical Engineering, Chemical Engineering, University of Washington, Seattle, Washington 98195-2600, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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