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首页> 外文期刊>Environmental Science & Technology >Isomer-Spedfic Biotransformation of Perfluorooctane Sulfonamide in Sprague-Dawley Rats
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Isomer-Spedfic Biotransformation of Perfluorooctane Sulfonamide in Sprague-Dawley Rats

机译：Sprague-Dawley大鼠全氟辛烷磺酰胺的异构体饱和生物转化

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摘要

Great variability exists in perfluorooctane sul-fonate (PFOS) isomer patterns in human and wildlife samples, including unexpectedly high percentages (e.g, >40%) of branched isomers in human sera. Previous in vitro tests showed that branched PFOS-precursors were biotransformed faster than the corresponding linear isomer. Thus, high percentages of branched PFOS may be a biomarker of PFOS-precursor exposure in humans. We evaluated this hypothesis by examining the isomer-specific fate of perfluorooctane sulfonamide (PFOSA), a known PFOS-precursor, in male Sprague-Dawley rats exposed to commercial PFOSA via food for 77 days (83.0 ± 20.4 ng kg~(-1) day~(-1)), followed by 27 days of depuration. Elimination half-lives of the two major branched PFOSA isomers (2.5 ±1.0 days and 3.7 ± 1.2 days) were quicker than for linear PFOSA (5.9 ± 4.6 days), resulting in a depletion of branched PFOSA isomers in blood and tissues relative to the dose. A corresponding increase in the total branched isomer content of PFOS, the ultimate metabolite, in rat serum was not observed. However, a significant enrichment of Sm-PFOS and a significant depletion of lm-PFOS were observed, relative to authentic electrochemical PFOS. The data cannot be directly extrapolated to humans, due to known differences in the tomokinetics of PFOS in rodents and humans. However, the results confirm that in vivo exposure to commercially relevant PFOS-precursors can result in a distinct PFOS isomer profile that may be useful as a biomarker of exposure source.
机译：人类和野生生物样品中的全氟辛烷磺酸（PFOS）异构体模式存在很大的差异性，包括人类血清中支链异构体的比例出乎意料的高（例如> 40％）。先前的体外测试表明，与相应的线性异构体相比，支化的PFOS前体的生物转化速度更快。因此，高百分比的分支全氟辛烷磺酸可能是人类体内全氟辛烷磺酸前体暴露的生物标志。我们通过检查公知的全氟辛烷磺酸前体全氟辛烷磺酰胺（PFOSA）的异构体特定命运来评估这一假设，该雄性Sprague-Dawley大鼠通过食物暴露于商业PFOSA中达77天（83.0±20.4 ng kg〜（-1）天〜（-1）），然后净化27天。两种主要的PFOSA异构体的消除半衰期（2.5±1.0天和3.7±1.2天）比线性PFOSA的消除半衰期（5.9±4.6天）要快，导致血液和组织中的PFOSA异构体相对于血红蛋白消耗减少剂量。未观察到大鼠血清中全氟辛烷磺酸（最终代谢物）的总支链异构体含量相应增加。然而，相对于真实的电化学PFOS，观察到Sm-PFOS的大量富集和lm-PFOS的显着耗尽。由于已知的啮齿动物和人类中全氟辛烷磺酸的断层动力学差异，因此无法将数据直接推断给人类。但是，结果证实，体内暴露于商业相关的PFOS前体可导致不同的PFOS异构体谱，可用作暴露源的生物标记。

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  • 来源
    《Environmental Science & Technology》 |2012年第6期|p.3196-3203|共8页
  • 作者

    Matthew S. Ross; Charles S. Wong; Jonathan W. Martin;

  • 作者单位

    University of Alberta, Department of Chemistry, Edmonton, Alberta T6G 2G2 Canada;

    University of Alberta, Department of Chemistry, Edmonton, Alberta T6G 2G2 Canada,Environmental Studies Program and Department of Chemistry, Richardson College for the Environment, University of Winnipeg, Winnipeg, Manitoba, R3B 2E9 Canada;

    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2G3 Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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