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Enhanced Biodegradation of Carbamazepine after UV/H_2O_2 Advanced Oxidation

机译:UV / H_2O_2高级氧化后卡马西平的增强生物降解作用

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摘要

Carbamazepine is one of the most persistent pharmaceutical compounds in wastewater effluents due to its resistance to biodegradation-based conventional treatment Advanced oxidation can efficiently degrade carbamazepine,but the toxidty and persistence of the oxidation products may be more relevant than the parent. This study sets out to determine whether the products of advanced oxidation of carbamazepine can be biotransformed and ultimately mineralized by developing a novel methodology to assess these sequential treatment processes. The methodology traces the transformation products of the ~(14)C-labeled carbamazepine during UV/hydrogen peroxide advanced oxidation and subsequent biotransformation by mixed, undefined cultures using liquid scintillation counting and liquid chromatography with radioactivity, mass spectrometry,and UV detectors. The results show that the oxidation byproducts of carbamazepine containing a hydroxyl or carbonyl group can be fully mineralized by a mixed bacterial inoculum. A tertiary treatment approach that includes oxidation and biotransformation has the potential to synergistically mineralize persistent pharmaceutical compounds in wastewater treatment plant effluents. The methodology developed for this study can be applied to assess the mineralization potential of other persistent organic contaminants.
机译:卡马西平由于对基于生物降解的常规处理具有抵抗力,因此是废水中最持久的药物化合物之一。高级氧化可以有效降解卡马西平,但氧化产物的氧化性和持久性可能比母体更重要。这项研究着手确定一种卡马西平高级氧化产物是否可以被生物转化,并最终通过开发一种评估这些连续治疗过程的新方法来最终矿化。该方法通过使用液体闪烁计数和具有放射活性的质谱,质谱和UV检测器进行混合,不确定的培养来追踪〜(14)C标记的卡马西平在UV /过氧化氢高级氧化和随后的生物转化过程中的转化产物。结果表明,含有羟基或羰基的卡马西平的氧化副产物可被混合细菌接种物充分矿化。包括氧化和生物转化在内的三级处理方法可能会协同矿化废水处理厂废水中的持久性药物化合物。为这项研究开发的方法可用于评估其他持久性有机污染物的矿化潜力。

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  • 来源
    《Environmental Science & Technology》 |2012年第11期|p.6222-6227|共6页
  • 作者单位

    Civil,Environmental,and Architectural Engineering,University of Colorado,Boulder,Colorado 80309,United States;

    Chemistry Department,University at Buffalo,The State University of New York,Buffalo,New York 14260,United States;

    Civil,Environmental,and Architectural Engineering,University of Colorado,Boulder,Colorado 80309,United States;

    Chemistry Department,University at Buffalo,The State University of New York,Buffalo,New York 14260,United States;

    Civil and Environmental Engineering Department,University of Michigan,Ann Arbor,Michigan 48109,United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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