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首页> 外文期刊>Environmental Science & Technology >Potential Role of Phospholipids in Determining the Internal Tissue Distribution of Perfluoroalkyl Acids in Biota
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Potential Role of Phospholipids in Determining the Internal Tissue Distribution of Perfluoroalkyl Acids in Biota

机译：磷脂在确定生物体内全氟烷基酸内部组织分布中的潜在作用

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摘要

Studies characterizing and quantifying the bioaccumulation and internal tissue distribution of perfluoroalkyl acids (PFAAs) remain highly relevant from both a scientific and regulatory perspective. Unlike neutral hydrophobic organic contaminants which exhibit the highest wet weight concentrations in adipose tissue, the highest levels of PFAAs in biota are typically measured in liver and blood samples. This pattern of internal tissue distribution is hypothesized to largely reflect the role of PFAA-protein interactions in determining the sorption capacity of the organism and its various organs. Based on recent work developing and evaluating a mechanistically based bioconcentration model for ionogenic organic chemicals (IOCs) in fish,~2 we propose an alternative hypothesis, namely that the bioaccumulation potential and internal tissue distribution of perfluoroalkyl acids (PFAAs) are strongly influenced by phospholipids. The objective of this Viewpoint is to encourage further empirical studies to evaluate this assertion.
机译：从科学和监管角度来看，表征和量化全氟烷基酸（PFAAs）的生物蓄积和内部组织分布的研究仍然高度相关。与在脂肪组织中表现出最高湿重浓度的中性疏水性有机污染物不同，通常在肝脏和血液样本中测量生物区中PFAA的最高水平。假设这种内部组织分布模式在很大程度上反映了PFAA-蛋白质相互作用在确定生物体及其各种器官的吸收能力中的作用。基于最近的工作，在开发和评估鱼类中离子有机化学物质（IOC）的基于机械的生物富集模型的基础上，〜2我们提出了另一种假设，即全氟烷基酸（PFAAs）的生物蓄积潜力和内部组织分布受磷脂的强烈影响。 。该观点的目的是鼓励进行进一步的实证研究以评估这一主张。

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  • 来源
    《Environmental Science & Technology》 |2012年第22期|12285-12286|共2页
  • 作者

    James M. Armitage; Jon A. Arnot; Frank Wania;

  • 作者单位

    Department of Physical & Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario, Canada, MIC 1A4;

    Department of Physical & Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario, Canada, MIC 1A4 ARC Arnot Research & Consulting, 36 Sproat Avenue, Toronto, Ontario, Canada, M4M 1W4;

    Department of Physical & Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario, Canada, MIC 1A4;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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