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Biotransformation of the Antiviral Drugs Acyclovir and Penciclovir in Activated Sludge Treatment

机译：抗病毒药物阿昔洛韦和喷昔洛韦在活性污泥处理中的生物转化

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摘要

The biotransformation of the two antiviral drugs, acyclovir (ACV) and penciclovir (PCV), was investigated in contact with activated sludge. Biodegradation kinetics were determined, and transformation products (TPs) were identified using Hybrid Linear Ion Trap- FT Mass Spectrometry (LTQ. Orbitrap Velos) and ID (fH NMR, 13C NMR) and 2D OH/H-COSY, 'H-^C-HSQC) NMR Spectroscopy. ACV and PCV rapidly dissipated in the activated sludge batch systems with half-lives of 5.3 and 3.4 h and first-order rate constants in relation to the amount of suspended solids (SS) of 4.9 ± 0.1 L gss"1 d"1 and 7.6 ± 0.3 Lg^"1 d"1, respectively. For ACV only a single TP was found, whereas eight TPs were identified for PCV. Structural elucidation of TPs exhibited that transformation only took place at the side chain leaving the guanine moiety unaltered. The oxidation of the primary hydroxyl group in ACV resulted in the formation of carboxy-acyclovir (Carboxy-ACV). For PCV, transformation was more diverse with several enzy- matic reactions taking place such as the oxidation of terminal hydroxyl groups and/3-oxidation followed by acetate cleavage. Analysis of different environmental samples revealed the presence of Carboxy-ACV in surface and drinking water with concentrations up to 3200 ng L ! and 40 ng L 1, respectively.
机译：研究了两种抗病毒药物阿昔洛韦（ACV）和喷昔洛韦（PCV）与活性污泥的生物转化。确定了生物降解动力学，并使用混合线性离子阱-FT质谱（LTQ。Orbitrap Velos）和ID（fH NMR，13C NMR）和2D OH / H-COSY，'H- ^ C鉴定了转化产物（TPs） -HSQC）NMR光谱。 ACV和PCV在活性污泥分批系统中迅速消散，半衰期为5.3和3.4 h，相对于悬浮固体（SS）量的一级速率常数为4.9±0.1 L gss“ 1 d” 1和7.6分别为±0.3Lg ^“ 1d” 1。对于ACV，仅找到一个TP，而为PCV确定了8个TP。 TPs的结构解析表明，转化仅发生在侧链，而鸟嘌呤部分未发生改变。 ACV中伯羟基的氧化导致形成羧基无环鸟苷（Carboxy-ACV）。对于PCV，转化过程更加多样化，发生了多种酶促反应，例如末端羟基的氧化和/ 3-氧化，然后乙酸酯裂解。对不同环境样品的分析表明，地表水和饮用水中存在的羧基ACV浓度高达3200 ng L！和40 ng L 1。

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  • 来源
    《Environmental Science & Technology》 |2011年第7期|p.2761-2769|共9页
  • 作者

    Carsten Prasse; Manfred Wagner; Ralf Schulz; Thomas A. Ternes;

  • 作者单位

    Federal Institute of Hydrology (BfG), Koblenz, Germany,Institute for Environmental Sciences, University of Koblenz-Landau, Landau, Germany;

    Max Planck Institute for Polymer Research, Mainz, Germany;

    Institute for Environmental Sciences, University of Koblenz-Landau, Landau, Germany;

    Federal Institute of Hydrology (BfG), Koblenz, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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