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首页> 外文期刊>FEMS Microbiology Letters >Pandemic pharmaceutical dosing effects on wastewater treatment: No adaptation of activated sludge bacteria to degrade the antiviral drug Oseltamivir (Tamiflu?) and loss of nutrient removal performance
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Pandemic pharmaceutical dosing effects on wastewater treatment: No adaptation of activated sludge bacteria to degrade the antiviral drug Oseltamivir (Tamiflu?) and loss of nutrient removal performance

机译：大流行药物剂量对废水处理的影响：活性污泥细菌无法适应降解抗病毒药物Oseltamivir（Tamiflu？）的作用，并失去营养去除性能

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摘要

The 2009-2010 influenza pandemic saw many people treated with antivirals and antibiotics. High proportions of both classes of drugs are excreted and enter wastewater treatment plants (WWTPs) in biologically active forms. To date, there has been no study into the potential for influenza pandemic-scale pharmaceutical use to disrupt WWTP function. Furthermore, there is currently little indication as to whether WWTP microbial consortia can degrade antiviral neuraminidase inhibitors when exposed to pandemic-scale doses. In this study, we exposed an aerobic granular sludge sequencing batch reactor, operated for enhanced biological phosphorus removal (EBPR), to a simulated influenza-pandemic dosing of antibiotics and antivirals for 8 weeks. We monitored the removal of the active form of Tamiflu?, oseltamivir carboxylate (OC), bacterial community structure, granule structure and changes in EBPR and nitrification performance. There was little removal of OC by sludge and no evidence that the activated sludge community adapted to degrade OC. There was evidence of changes to the bacterial community structure and disruption to EBPR and nitrification during and after high-OC dosing. This work highlights the potential for the antiviral contamination of receiving waters and indicates the risk of destabilizing WWTP microbial consortia as a result of high concentrations of bioactive pharmaceuticals during an influenza pandemic.
机译：2009-2010年的流感大流行使许多人接受了抗病毒药和抗生素的治疗。这两类药物中有很大一部分以生物活性形式排泄并进入废水处理厂（WWTP）。迄今为止，尚未进行关于流感大流行规模药物用于破坏WWTP功能的潜力的研究。此外，目前几乎没有迹象表明当暴露于大流行规模的剂量时，WWTP微生物联盟是否可以降解抗病毒神经氨酸酶抑制剂。在这项研究中，我们将需氧颗粒污泥测序分批反应器（用于增强生物除磷（EBPR）的操作）暴露于模拟的流感大流行抗生素和抗病毒药剂量，为期8周。我们监测了达菲的活性形式，奥司他韦羧酸盐（OC），细菌群落结构，颗粒结构的去除以及EBPR和硝化性能的变化。污泥几乎没有去除OC，也没有证据表明活性污泥群落可以降解OC。有证据表明，在高OC剂量期间和之后，细菌群落结构发生变化，EBPR和硝化作用受到破坏。这项工作凸显了接受水域抗病毒污染的潜力，并指出了在流感大流行期间由于高浓度的生物活性药物而使WWTP微生物群落不稳定的风险。

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