...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Genotoxicity of Several Polybrominated Diphenyl Ethers (PBDEs) and Hydroxylated PBDEs, and Their Mechanisms of Toxicity
【24h】

Genotoxicity of Several Polybrominated Diphenyl Ethers (PBDEs) and Hydroxylated PBDEs, and Their Mechanisms of Toxicity

机译：几种多溴联苯醚（PBDEs）和羟基化PBDEs的遗传毒性及其毒性机理

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Polybrominated diphenyl ethers (PBDEs) have been extensively utilized as flame retardants, and recently there has been concern about potential adverse effects in humans and wildlife. Their hydroxylated analogs (OH-BDEs) have received increasing attention due to their potential for endocrine and neurological toxicities. However, the potentials and mechanisms of genotoxicity of these brominated compounds have scarcely been investigated. In the present study, genotoxicity of tetra-BDEs, penta BDE, octa-BDE, deca-BDE, and tetra-OH-BDEs were investigated by use of chicken DT40 cell lines including wild-type cells and a panel of mutant cell lines deficient in DNA repair pathways. Tetra-BDEs have greater genotoxic potential than do the other BDEs tested. OH-tetra-BDEs were more genotoxic than tetra-BDEs. DT40 cells, deficient in base excision repair (Po//?"7") and translesion DNA synthesis (REV3~/~) pathways, were hypersensitive to the genotoxic effects of tetra-BDEs and OH-tetra-BDEs. The observation of chromosomal aberrations and gamma-H_2AX assay confirmed that the studied brominated compounds caused double strand breaks. Pretreatment with N-acetyl-L-cysteine (NAC) significantly rescued the Pol^~l~ and REV3^'~ mutants, which is consistent with the hypothesis that PBDEs and OH-BDEs cause DNA damage mediated through reactive oxygen species (ROS). Some tetra-BDEs and OH-tetra-BDEs caused base damage through ROS leading to replication blockage and subsequent chromosomal breaks.
机译：多溴二苯醚（PBDEs）已被广泛用作阻燃剂，最近人们对人类和野生动植物的潜在不利影响感到关注。它们的羟基化类似物（OH-BDEs）由于其潜在的内分泌和神经毒性而受到越来越多的关注。但是，几乎没有研究过这些溴化化合物的遗传毒性的潜力和机理。在本研究中，通过使用鸡DT40细胞系（包括野生型细胞和一组缺陷的突变细胞系）研究了四溴联苯醚，五溴联苯醚，八溴联苯醚，十溴联苯醚，十溴联苯醚和四羟基乙苯醚的遗传毒性。在DNA修复途径中四溴联苯醚的遗传毒性潜力比其他测试过的溴联苯醚更大。 OH-四溴联苯醚比四溴联苯醚更具遗传毒性。 DT40细胞缺乏碱基切除修复（Po //？“ 7”）和跨病变DNA合成（REV3 //）途径，对四溴联苯醚和OH-四溴联苯醚的遗传毒性作用非常敏感。染色体畸变和γ-H_2AX分析的观察证实，所研究的溴化化合物引起双链断裂。用N-乙酰基-L-半胱氨酸（NAC）预处理可以挽救Pol ^〜l〜和REV3 ^'〜突变体，这与PBDEs和OH-BDEs引起通过活性氧（ROS）介导的DNA损伤的假设相一致。 。一些四溴联苯醚和OH-四溴联苯醚通过ROS引起碱基破坏，从而导致复制受阻和随后的染色体断裂。

著录项

  • 来源
    《Environmental Science & Technology》 |2011年第11期|p.5003-5008|共6页
  • 作者

    Kyunghee Ji; Kyungho Choi; John P. Giesy; Javed Musarrat; Shunichi Takeda;

  • 作者单位

    School of Public Health, Seoul National University, Seoul, 151-742, Korea;

    Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan,S7J 5B3, Canada;

    Department of Zoology, and Center for Integrative Toxicology, Michigan State University, East Lansing, MI, USA,Zoology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;

    Zoology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;

    Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号